Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis [PDF]
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
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Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy [PDF]
Frontiers in Immunology, 2019 The immune system plays pivotal roles in the occurrence and progression of cancers. As blockade of immune-checkpoint has been proven effective at improving anti-tumor immune response in multiple tumor types, the tumor immunotherapy still faces many ...
Liangbin Lin +3 more
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The roles of tertiary lymphoid structures in orchestrating immune responses in peripheral organs [PDF]
Inflammation and RegenerationTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that develop in non-lymphoid organs under pathological conditions of chronic inflammation, such as cancer, autoimmune diseases, chronic infections, organ transplantation, and age-related
Keisuke Taniguchi +2 more
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Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice. [PDF]
PLoS ONE, 2014 A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown.
Yuan Huang +9 more
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Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis [version 3; referees: 2 approved] [PDF]
F1000Research, 2018 Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization of peripheral immune cells involved in the activity of the disease cascade but their spectrum of action in the ...
Ana C. Londoño, Carlos A. Mora
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Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection.
Gareth Wyn Jones +2 more
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Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Dennis Gruszka +2 more
exaly +2 more sources
Metachronous bilateral renal cancer with immune checkpoint blockade-mediated eradication of bone metastasis: case report [PDF]
Frontiers in OncologyBackgroundThe immune landscape of renal cell carcinoma (RCC) is a key determinant of response to immune checkpoint inhibitors (ICIs). Yet, direct comparisons of immune infiltrates across histologic subtypes and metastatic sites within the same patient ...
Dimitar Metodiev +15 more
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Frontiers in Immunology, 2016 High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition.
Nancy H Ruddle
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Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis [PDF]
Frontiers in ImmunologySystemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterised by loss of tolerance, widespread immune dysregulation, and production of diverse autoantibodies (typically directed against nuclear components).
Fareeha Tariq +5 more
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