Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis [PDF]
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
doaj +5 more sources
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice. [PDF]
PLoS ONE, 2014 A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown.
Yuan Huang +9 more
doaj +2 more sources
Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis [version 3; referees: 2 approved] [PDF]
F1000Research, 2018 Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization of peripheral immune cells involved in the activity of the disease cascade but their spectrum of action in the ...
Ana C. Londoño, Carlos A. Mora
doaj +2 more sources
Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection.
Gareth Wyn Jones +2 more
doaj +2 more sources
Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Dennis Gruszka, Abigail Basson
exaly +2 more sources
Frontiers in NeurosciencePostmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in the meninges of patients with progressive multiple sclerosis, playing an important role in the pathophysiology of the disease.
Ana C. Londoño +2 more
doaj +3 more sources
Formation and remodeling of immunological niches in solid tumors: organ-specific architectures, inflammatory parallels, and therapeutic reprogramming [PDF]
Frontiers in ImmunologyTumor immunity is increasingly understood not only through the cellular composition of the tumor microenvironment, but also through spatially organized local niches that can help determine where immune recognition is initiated, constrained, suppressed ...
Zhuo Zhang +5 more
doaj +2 more sources
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer [PDF]
British Journal of Cancer, 2015 Y Ino, T Kosuge, N Hiraoka
exaly +2 more sources
Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
doaj +1 more source
Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy
Frontiers in Immunology, 2023 ILC3s have been identified as crucial immune regulators that play a role in maintaining host homeostasis and modulating the antitumor response. Emerging evidence supports the idea that LTi cells play an important role in initiating lymphoid tissue ...
Yunshu Zhang +9 more
doaj +1 more source