Results 41 to 50 of about 8,187 (242)

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes [PDF]

Diabetologia, 2021
AbstractAims/hypothesisWe and others previously reported the presence of tertiary lymphoid organs (TLOs) in the pancreas of NOD mice, where they play a role in the development of type 1 diabetes. Our aims here are to investigate whether TLOs are present in the pancreas of individuals with type 1 diabetes and to characterise their distinctive features ...
Éva Korpos, Nadir Kadri, Sophie Loismann, Clais R. Findeisen, Frank Arfuso, George W. Burke, Sarah J. Richardson, Noel G. Morgan, Marika Bogdani, Alberto Pugliese, Lydia Sorokin   +10 more
openaire   +2 more sources

Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid‐Based Immunotherapy to Enhance Anti‐Tumor Immunity

Advanced Science, 2022
Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses for patients undergoing cancer immunotherapy.
Jae‐Won Lee, Bum Chul Park, Na Yoon Jang, Sihyeon Lee, Young Kyu Cho, Prashant Sharma, Sang Won Byun, Kyeongseok Jeon, Yun‐Hui Jeon, Uni Park, Hyo Jin Ro, Hyo Ree Park, Yuri Kim, Dong‐Sup Lee, Seok Chung, Young Keun Kim, Nam‐Hyuk Cho   +16 more
doaj   +1 more source

Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis [PDF]

Circulation
Yao Lu, Qingzhong Xiao, Jingjing Cai
exaly   +2 more sources

P03.03 Organization, function and gene expression of tertiary lymphoid structures in PDAC resembles lymphoid follicles in secondary lymphoid organs [PDF]

E-Poster Presentations, 2020
Background Secondary lymphoid organs (SLO) are involved in induction and enhancement of anti-tumor immune responses on different tumor entities. Recent evidence suggests that anti-tumor immune responses may also be induced or enhanced in the tumor microenvironment in so called tertiary lymphoid structures (TLS).
M Thelen, MA García-Márquez, T Nestler, S Wagener-Ryczek, J Lehmann, E Staib, F Popp, F Gebauer, P Lohneis, M Odenthal, S Merkelbach-Bruse, C Bruns, K Wennhold, M von Bergwelt-Baildon, HA Schlößer   +14 more
openaire   +1 more source

Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ.
Hong Feng, Hong Feng, Fujun Yang, Lihong Qiao, Kai Zhou, Kai Zhou, Junfei Wang, Jiao Zhang, Tian Tian, Ying Du, Hong Shangguan   +10 more
doaj   +1 more source

Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis [version 2; referees: 2 approved]

F1000Research, 2018
Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization of peripheral immune cells involved in the activity of the disease cascade but their spectrum of action in the ...
Ana C. Londoño, Carlos A. Mora
doaj   +1 more source

New Insights on the Pathogenesis of Takayasu Arteritis: Revisiting the Microbial Theory

Pathogens, 2018
Takayasu arteritis (TAK) is a chronic vasculitis that mainly affects the aorta, its major branches, and the pulmonary arteries. Since the description of the first case by Mikito Takayasu in 1908, several aspects of this rare disease, including the ...
J. Luis Espinoza, Suzue Ai, Itaru Matsumura   +2 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

IL-17, a new kid on the block of tertiary lymphoid organs [PDF]

Cellular & Molecular Immunology, 2011
Tertiary lymphoid organs (TLOs) are structures that resemble lymph nodes that can be found in chronically inflamed tissues in a number of inflammatory conditions. TLOs can host ongoing immune responses that can potentially contribute to disease pathogenesis.
Theresa T, Lu, Hajeong, Kim, Xiaojing, Ma   +2 more
openaire   +2 more sources

The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal Cancer

Frontiers in Immunology, 2019
The Crohn's-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC.
Asaf Maoz, Michael Dennis, Joel K. Greenson   +2 more
doaj   +1 more source