Results 31 to 40 of about 8,169 (239)
Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy. [PDF]
Clin J Am Soc Nephrol, 2014 Previous studies have identified inflammatory features that enable the prediction of renal outcome of IgA nephropathy (IgAN); however, validation of these findings is still needed. This prospective study was performed to determine the characteristics of renal interstitial infiltration and tertiary lymphoid organ (TLO) neogenesis in a cohort of Chinese ...
Pei G +11 more
europepmc +4 more sources
Tertiary Lymphoid Organs in Central Nervous System Autoimmunity [PDF]
Frontiers in Immunology, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients. Autoreactive T cells are important drivers of the disease; however, the efficacy of B cell depleting therapies uncovered an essential role for B ...
Meike Mitsdoerffer +2 more
openaire +4 more sources
Stroma cell priming in enteric lymphoid organ morphogenesis
Frontiers in Immunology, 2012 The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses.
Manuela eFerreira +2 more
doaj +1 more source
B cells and tertiary lymphoid organs in renal inflammation [PDF]
Kidney International, 2008 B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy.
Segerer, S., Schlöndorff, D.
openaire +2 more sources
Frontiers in Immunology, 2012 In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary lymphoid organs (SLOs), is compared to that of tertiary lymphoid tissue or organs (TLOs), also ...
Sharon eStranford, Nancy H. Ruddle
doaj +1 more source
Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
Frontiers in Immunology, 2022 Type 1 diabetes (T1D) stems from pancreatic β cell destruction by islet reactive immune cells. Similar as other autoimmune disorders, there is no curative remedy for T1D thus far.
Shi-Wei Liu +4 more
doaj +1 more source
Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation.
Frontiers in Immunology, 2016 Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone +5 more
doaj +1 more source
Lymphatic vessels and tertiary lymphoid organs [PDF]
Journal of Clinical Investigation, 2014 Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs). Although acute inflammation can result in defective LVs, TLO LVs appear to function normally in that they drain fluid and transport cells that ...
openaire +2 more sources
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs ...
Catherine Hughes +5 more
openaire +6 more sources
Frontiers in Immunology, 2023 In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang +13 more
doaj +1 more source