Results 31 to 40 of about 8,187 (242)
Stroma cell priming in enteric lymphoid organ morphogenesis
Frontiers in Immunology, 2012 The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses.
Manuela eFerreira +2 more
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B cells and tertiary lymphoid organs in renal inflammation [PDF]
Kidney International, 2008 B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy.
Segerer, S., Schlöndorff, D.
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Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
Frontiers in Immunology, 2022 Type 1 diabetes (T1D) stems from pancreatic β cell destruction by islet reactive immune cells. Similar as other autoimmune disorders, there is no curative remedy for T1D thus far.
Shi-Wei Liu +4 more
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Lymphatic vessels and tertiary lymphoid organs [PDF]
Journal of Clinical Investigation, 2014 Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs). Although acute inflammation can result in defective LVs, TLO LVs appear to function normally in that they drain fluid and transport cells that ...
openaire +2 more sources
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Ectopic clusters of immune cells that mimic the structure and function of secondary lymphoid organs are defined as tertiary lymphoid organs (TLOs). They have been observed at sites of chronic inflammation for decades, but their formation and function have remained enigmatic.
Barone Francesca +17 more
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Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs ...
Catherine Hughes +5 more
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Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation.
Frontiers in Immunology, 2016 Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone +5 more
doaj +1 more source
Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity [PDF]
Frontiers in Immunology, 2017 No abstract available.
Yin, Changjun +3 more
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Role of tertiary lymphoid organs in the regulation of immune responses in the periphery
Cellular and Molecular Life Sciences, 2022 Tertiary lymphoid organs (TLOs) are collections of immune cells resembling secondary lymphoid organs (SLOs) that form in peripheral, non-lymphoid tissues in response to local chronic inflammation. While their formation mimics embryologic lymphoid organogenesis, TLOs form after birth at ectopic sites in response to local inflammation resulting in their ...
Amit I. Bery +5 more
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BMC Immunology, 2020 Background Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers formation in the secondary ...
Dmitrii Borisovich Chudakov +5 more
doaj +1 more source