Results 11 to 20 of about 8,803 (251)
Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy [PDF]
Frontiers in Immunology, 2019 The immune system plays pivotal roles in the occurrence and progression of cancers. As blockade of immune-checkpoint has been proven effective at improving anti-tumor immune response in multiple tumor types, the tumor immunotherapy still faces many ...
Liangbin Lin +3 more
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The roles of tertiary lymphoid structures in orchestrating immune responses in peripheral organs
Inflammation and RegenerationTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that develop in non-lymphoid organs under pathological conditions of chronic inflammation, such as cancer, autoimmune diseases, chronic infections, organ transplantation, and age-related
Keisuke Taniguchi +2 more
doaj +4 more sources
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]
Frontiers in Immunology, 2016 The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Koenig, Alice, Thaunat, Olivier
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Tertiary Lymphoid Organs in Takayasu Arteritis [PDF]
Frontiers in Immunology, 2016 The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients.Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs.
Marc eClement +15 more
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Tertiary Lymphoid Organs in Rheumatoid Arthritis [PDF]
, 2020 Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo-angiogenesis, and immune cell infiltration that drives local inflammation and, if untreated, can lead to joint destruction and disability.
Rivellese, F, Pontarini, E, Pitzalis, C
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Tertiary Lymphoid Organs in Cancer Tissues [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer ...
Hiraoka, Nobuyoshi +2 more
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Tertiary lymphoid organs in infection and autoimmunity [PDF]
Trends in Immunology, 2012 The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation.
Katrijn Neyt +4 more
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The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
Frontiers in Immunology, 2021 There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment.
Roger Li +10 more
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IL-17 initiates tertiary lymphoid organ formation. [PDF]
Cell Mol Immunol, 2012 Chronic inflammatory infiltrates that take on the form of organized lymphoid organs are called tertiary lymphoid organs (TLOs). The inflammatory cytokine interleukin-17 is now found to be the critical participant driving the development of a type of TLO called inducible bronchus-associated lymphoid tissue (iBALT) in an animal model of neonatal ...
Zhang X, Lu B.
europepmc +4 more sources
Tertiary Lymphoid Organs in Lymphatic Malformations [PDF]
Lymphatic Research and Biology, 2011 Examine lymphatic malformation lymphoid aggregates for the expression of tertiary lymphoid organ markers. Determine how lymphoid aggregate density relates to lymphatic malformation clinical features.Retrospective cohort study. Tissue and clinical data were reviewed from 29 patients in the Vascular Anomaly Database who represented the spectrum of head ...
Andrew L, Kirsh +4 more
openaire +2 more sources