Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer [PDF]
British Journal of Cancer, 2015 N Hiraoka +2 more
exaly +2 more sources
Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications [PDF]
Frontiers in ImmunologyInterstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory ...
Yaxin Cheng +10 more
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Chronic inflammation is involved in the development of abdominal aortic aneurysm (AAA). A tertiary lymphoid structure (TLS) within vascular lesions has recently been focused on for its role in modulation of inflammation in local tissues.
Itaru Hosaka +20 more
doaj +3 more sources
Tertiary lymphoid structures guided opportunities and challenges for immunotherapy in early gastroesophageal junction cancer and low rectal cancer [PDF]
Human Vaccines & ImmunotherapeuticsEarly-stage gastroesophageal junction cancer (GEJC) and low rectal cancer (LRC) pose a dilemma: surgery is often curative yet may cause lasting functional loss.
Qi Zou +8 more
doaj +2 more sources
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum [PDF]
Journal of Experimental MedicineGuilherme Pedrón Formigari +2 more
exaly +2 more sources
IL-17 initiates tertiary lymphoid organ formation. [PDF]
Cell Mol Immunol, 2012 Chronic inflammatory infiltrates that take on the form of organized lymphoid organs are called tertiary lymphoid organs (TLOs). The inflammatory cytokine interleukin-17 is now found to be the critical participant driving the development of a type of TLO called inducible bronchus-associated lymphoid tissue (iBALT) in an animal model of neonatal ...
Zhang X, Lu B.
europepmc +4 more sources
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]
Frontiers in Immunology, 2016 The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Koenig, Alice, Thaunat, Olivier
openaire +2 more sources
Tertiary Lymphoid Organs in Takayasu Arteritis [PDF]
Frontiers in Immunology, 2016 The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients.Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs.
Marc eClement +15 more
openaire +3 more sources
Tertiary Lymphoid Organs in Rheumatoid Arthritis [PDF]
, 2020 Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo-angiogenesis, and immune cell infiltration that drives local inflammation and, if untreated, can lead to joint destruction and disability.
Rivellese, F, Pontarini, E, Pitzalis, C
openaire +3 more sources
Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
doaj +1 more source