Tertiary lymphoid organs in Takayasu Arteritis [PDF]
Frontiers in Immunology, 2016 Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients.Methods: Hematoxylin and eosin–stained sections from aorta
Marc eClement +15 more
doaj +7 more sources
Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity [PDF]
Frontiers in Immunology, 2016 Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well structured lymph node-like though unencapsulated lymphoid tissues.
Changjun Yin +6 more
doaj +8 more sources
Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes +5 more
doaj +10 more sources
Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon [PDF]
Frontiers in Immunology, 2016 The immune system of the gut has evolved a number of specific lymphoid structures that contribute to homeostasis in the face of microbial colonization and food-derived antigenic challenge. These lymphoid organs encompass Peyer’s patches (PP) in the small
Manuela Buettner, Matthias Lochner
doaj +8 more sources
Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs [PDF]
Frontiers in Immunology, 2022 Ectopic tertiary lymphoid organs (TLOs) have been identified in many organs, such as the lungs, nasal cavities, and kidneys of both mice and humans. Although lymphocyte aggregates have been observed in the mammary glands of ruminants, the details remain ...
Yusaku Tsugami +4 more
doaj +4 more sources
Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation [PDF]
Frontiers in Immunology, 2017 Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in that they lack a mantle ...
Jawaher Alsughayyir +4 more
doaj +4 more sources
Gel-trapped lymphorganogenic chemokines trigger artificial tertiary lymphoid organs and mount adaptive immune responses in vivo [PDF]
Frontiers in Immunology, 2016 We previously generated artificial lymph node-like tertiary lymphoid organs (artTLOs) in mice using lymphotoxin α-expressing stromal cells. Here, we show the construction of transplantable and functional artTLOs by applying soluble factors trapped in ...
Takeshi Watanabe
doaj +4 more sources
Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis [PDF]
Frontiers in Immunology, 2019 Giant cell arteritis (GCA) can be classified into Cranial(C)-GCA and Large Vessel(LV)-GCA. Based on analysis of temporal arteries, GCA is postulated to be T-cell-mediated.
Jacoba C. Graver +6 more
doaj +4 more sources
High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation [PDF]
Frontiers in Immunology, 2016 High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition.
Nancy H Ruddle
doaj +4 more sources
Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective? [version 1; referees: 2 approved] [PDF]
F1000Research, 2017 Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
William D. Shipman +2 more
doaj +2 more sources