Results 11 to 20 of about 9,713 (217)
Tertiary Lymphoid Organs in Central Nervous System Autoimmunity [PDF]
Frontiers in Immunology, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Meike Mitsdoerffer +2 more
doaj +6 more sources
Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy [PDF]
Frontiers in Immunology, 2019 The immune system plays pivotal roles in the occurrence and progression of cancers. As blockade of immune-checkpoint has been proven effective at improving anti-tumor immune response in multiple tumor types, the tumor immunotherapy still faces many ...
Liangbin Lin +3 more
doaj +5 more sources
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]
Frontiers in Immunology, 2016 The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Olivier Thaunat +2 more
exaly +5 more sources
Tertiary Lymphoid Organs in Cancer Tissues [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer ...
Nobuyoshi Hiraoka +2 more
exaly +5 more sources
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Ectopic clusters of immune cells that mimic the structure and function of secondary lymphoid organs are defined as tertiary lymphoid organs (TLOs). They have been observed at sites of chronic inflammation for decades, but their formation and function have remained enigmatic.
Christopher D Buckley +2 more
exaly +6 more sources
Graph-based description of tertiary lymphoid organs at single-cell level. [PDF]
PLoS Computational Biology, 2020 Our aim is to complement observer-dependent approaches of immune cell evaluation in microscopy images with reproducible measures for spatial composition of lymphocytic infiltrates.
Nadine S Schaadt +7 more
doaj +2 more sources
Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors [PDF]
Journal for ImmunoTherapy of Cancer, 2019 Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara +4 more
doaj +2 more sources
Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
doaj +4 more sources
Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection [PDF]
JCI InsightSolid organ transplantation remains the life-saving treatment for end-stage organ failure, but chronic rejection remains a major obstacle to long-term allograft outcomes and has not improved substantially.
Gang Zhang +7 more
doaj +2 more sources
Posttransplant Tertiary Lymphoid Organs. [PDF]
Transplantation, 2023 Tertiary lymphoid organs (TLOs), also known as tertiary or ectopic lymphoid structures or tissues, are accumulations of lymphoid cells in sites other than canonical lymphoid organs, that arise through lymphoid neogenesis during chronic inflammation in autoimmunity, microbial infection, cancer, aging, and transplantation, the focus of this review. Lymph
Ruddle NH.
europepmc +3 more sources