Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs [PDF]
Frontiers in Immunology, 2016 The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Alice Koenig +2 more
exaly +5 more sources
Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon [PDF]
Frontiers in Immunology, 2016 The immune system of the gut has evolved a number of specific lymphoid structures that contribute to homeostasis in the face of microbial colonization and food-derived antigenic challenge. These lymphoid organs encompass Peyer’s patches (PP) in the small
Manuela Buettner, Matthias Lochner
doaj +6 more sources
Tertiary Lymphoid Organs in Cancer Tissues [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer ...
Nobuyoshi Hiraoka +2 more
exaly +5 more sources
Tertiary Lymphoid Organs Are Associated With Bacterial Dysbiosis in Chronic Rhinosinusitis [PDF]
International Forum of Allergy and RhinologyISSN:2042 ...
Sathish Paramasivan +2 more
exaly +6 more sources
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Ectopic clusters of immune cells that mimic the structure and function of secondary lymphoid organs are defined as tertiary lymphoid organs (TLOs). They have been observed at sites of chronic inflammation for decades, but their formation and function have remained enigmatic.
Francesca Barone +2 more
exaly +6 more sources
Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors [PDF]
Journal for ImmunoTherapy of Cancer, 2019 Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara +4 more
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Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
doaj +4 more sources
Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection [PDF]
JCI InsightSolid organ transplantation remains the life-saving treatment for end-stage organ failure, but chronic rejection remains a major obstacle to long-term allograft outcomes and has not improved substantially.
Gang Zhang +7 more
doaj +2 more sources
Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis [PDF]
Frontiers in Immunology, 2019 Giant cell arteritis (GCA) can be classified into Cranial(C)-GCA and Large Vessel(LV)-GCA. Based on analysis of temporal arteries, GCA is postulated to be T-cell-mediated.
Jacoba C. Graver +6 more
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High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation [PDF]
Frontiers in Immunology, 2016 High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition.
Nancy H Ruddle
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