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Tertiary Lymphoid Organs promote allograft rejection
The Journal of ImmunologyAbstract Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues and are frequently observed in tissue affected by non-resolving chronic inflammation. If TLOs are beneficial or detrimental in transplantation is controversial.
Neda Feizi +5 more
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B Cell Survival in Intragraft Tertiary Lymphoid Organs After Rituximab Therapy
Transplantation, 2008Rituximab is emerging as a potent therapeutic option in chronic inflammatory diseases associated with a prominent humoral component. Recent studies have demonstrated that chronic inflammatory infiltrate organize progressively themselves into ectopic lymphoid tissues (tertiary lymphoid organs; TLOs) supporting a local humoral immune response.
Olivier, Thaunat +11 more
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Annals of the Rheumatic Diseases, 2015
Background Tertiary lymphoid organs (TLOs) are organized clusters of immune cells that preferentially form in autoimmune diseases such as Sjogren9s syndrome (SS). TLOs are believed to contribute to disease progression and lymphoma development in SS. Within TLOs, the ectopic expression of lymphoid chemokines has been shown to correlate with size/degree
S. Nayar +8 more
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Background Tertiary lymphoid organs (TLOs) are organized clusters of immune cells that preferentially form in autoimmune diseases such as Sjogren9s syndrome (SS). TLOs are believed to contribute to disease progression and lymphoma development in SS. Within TLOs, the ectopic expression of lymphoid chemokines has been shown to correlate with size/degree
S. Nayar +8 more
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SAT0023 Artery Tertiary Lymphoid Organs Occur in Giant Cell Arteritis
Annals of the Rheumatic Diseases, 2016Background Arteries are immuno-privileged sites. In advanced atherosclerotic lesions, however, adventitial lymphoid infiltrates, sometimes aggregated in lymphoid follicles (the so called artery tertiary lymphoid organs, ATLO), occur together with marked neoangiogenesis and lymphangiogenesis, and with the extensive induction of high endothelial venules.
F. Ciccia +8 more
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Expression and function of interleukin-7 in secondary and tertiary lymphoid organs
Seminars in Immunology, 2012Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery.
Huang Hsin-Ying, Luther Sanjiv A
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The thymus in autoimmune Myasthenia Gravis: Paradigm for a tertiary lymphoid organ
Revue Neurologique, 2013In autoimmune Myasthenia Gravis (MG), a neuromuscular disease generally mediated by autoantibodies against the acetylcholine receptor (AChR), the muscle is the target organ of the autoimmune attack, while the thymus seems to be the primary production site of the autoantibodies.
J-M, Weiss +3 more
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Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles
Chemical Society Reviews, 2021Weichao Xue, Xiao Jia, Xuan Wang
exaly
[Meningeal tertiary lymphoid organs: Major actors in intrathecal autoimmunity].
Revue neurologique, 2015Multiple sclerosis (MS) is characterized by an intrathecal synthesis of immunoglobulins synthesized by B-cell clones and by a brain infiltrate of clonal T-cells. The clonal maturation of these lymphocytes takes place in tertiary lymphoid organs (TLO) developed in the intrathecal compartment.
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