Results 301 to 310 of about 29,370 (346)

Immune Scoring Model for Predicting Tertiary Lymphoid Structures and Neoadjuvant Therapy Response in Breast Cancer: A Radiomics and Deep Learning Approach

Yushuai Yu, Qing Wang, Yidan Lin, Kaiyan Huang, Jie Zhang, Chenxi Wang, Ruiliang Chen, Shuai Guo, Xuan Zeng, Xinyi Li, Meng Fan, Hengyu Zhang, Junhui Yuan, Chuangui Song   +13 more
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The landscape of tertiary lymphoid structures in endometrial cancer revealed through harmonized multi-level transcriptomics

Requesens M, Brummel K, Bhattacharya A, Somefun F, van Rooij N, Plat A, van der Hall DMX, Vledder A, Wardenaar R, Spierings DC, Berezikov E, Bosse T, Foijer F, Bart J, Nijman HW, Fehrmann RS, de Bruyn M.   +16 more
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Tertiary lymphoid structures in cancer

Science, 2022
Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
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Tfh cells induce intratumoral tertiary lymphoid structures

Trends in Immunology, 2022
Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4+ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor ...
Lisa, Schmidleithner, Markus, Feuerer
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Tertiary Lymphoid Structures Validated as Biomarker

Cancer Discovery, 2023
Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
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Tertiary lymphoid structures in cancer and beyond

Trends in Immunology, 2014
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Marie-Caroline, Dieu-Nosjean, Jérémy, Goc, Nicolas A, Giraldo, Catherine, Sautès-Fridman, Wolf Herman, Fridman   +4 more
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Tertiary lymphoid structures in anticancer immunity

Nature Reviews Cancer
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud, Ana Houel, Marylou Panouillot, Clémence Riffard, Marie-Caroline Dieu-Nosjean   +4 more
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Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

2018
Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang, Xiangyan, Qiu, Casey, Timmerman, Yang-Xin, Fu   +3 more
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Maturation of Tertiary Lymphoid Structures

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local
Daniel H, Shu, Dimitrios N, Sidiropoulos
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

2018
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez, Troy D, Randall, Selene, Meza-Perez   +2 more
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