Results 111 to 120 of about 798,978 (348)

A study of the observable axial- and equatorial-2,4-dimethyl-2-adamantyl cations. Further examples of equilibrating nonclassical structures in "ordinary" tertiary carbocations [PDF]

, 1990
D. J. Buffam, Ted S. Sorensen, S. Whitworth   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tertiary lymphoid structures in gliomas: impact on tumour immunity and progression

Journal of Translational Medicine
Tertiary lymphoid structures (TLSs) are ectopic lymphoid formations that develop in chronically inflamed tissues, including various solid tumours. In the context of gliomas, the presence of TLSs has recently attracted considerable attention because of ...
Jiatong Chen, Yuechao Yang, Shuang Luan, Wenhao Xu, Yang Gao   +4 more
doaj   +1 more source

203 Immune-mesenchymal crosstalk contribute to the expansion of autoreactive plasma cells in the tertiary lymphoid structures in Hidradenitis Suppurativa [PDF]

, 2023
W. Yu, John Barrett, Michelle Lin, Meaghan Marohn, Jason Devlin, A. Harrera, Juliana Remark, James G. Krueger, Kelly V. Ruggles, Sergei B. Koralov, Ernest S. Chiu, Ping Lu   +11 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Modeling of tertiary and quaternary protein structures by homology [PDF]

, 2012
Florian Kiefer
openalex   +1 more source

Prognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis [PDF]

, 2021
Nana Zhang, Fengjin Qu, Hao Liu, Zhujun Li, Yuchi Zhang, Xuan Han, Ziyu Zhu, Yi Lv   +7 more
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Spatial Differentiation and Influencing Factors of Tertiary Industry in the Pearl River Delta Urban Agglomeration

Land
The tertiary industry has become the main driving force for China’s economic development, and the adjustment and optimization of its structure are important prerequisites for achieving high-quality economic development.
Xiaodie Yuan, Baoyu Chen, Xiong He, Guojun Zhang, Chunshan Zhou   +4 more
doaj   +1 more source

Tree decomposition and parameterized algorithms for RNA structure-sequence alignment including tertiary interactions and pseudoknots [PDF]

, 2012
We present a general setting for structure-sequence comparison in a large class of RNA structures that unifies and generalizes a number of recent works on specific families on structures.
Barth, Dominique, Denise, Alain, Ponty, Yann, Rinaudo, Philippe   +3 more
core   +3 more sources