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Tertiary lymphoid structures in cancer
Science, 2022Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
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Protein Tertiary Structure Prediction
Current Protocols in Protein Science, 2000AbstractThis unit addresses how to predict the tertiary structure of a protein from its amino acid sequence using computational methods. Three types of prediction methods‐‐homology modeling, fold recognition, and ab initio prediction‐‐are introduced.
D, Xu, Y, Xu
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Protein Tertiary Structure Modeling
Current Protocols in Protein Science, 2001AbstractInsights into the 3D‐structure of a protein have proven useful during experiment design. Experimentally elucidated structures are often not available, but comparative protein modeling provides a viable alternative in many cases. This unit presents comparative protein modeling and how to use the highly sophisticated but easy‐to‐use free software
Guex, N., Schwede, T., Peitsch, M. C.
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Serpin tertiary structure transformation
Journal of Molecular Biology, 1991Previous crystallographic analyses have demonstrated that proteolytic cleavage of the serpins can result in a dramatic transformation of their tertiary structure. Some 16 residues on the amino terminal side of the cleavage site are inserted into a large beta-sheet to become a central strand, separating the two cleaved residues by about 70 A.
P, Stein, C, Chothia
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Calculation of protein tertiary structure
Journal of Molecular Biology, 1976Abstract We describe a method for calculating the tertiary structure of proteins given their amino acid sequence. The algorithm involves locally minimizing an energylike expression as a function of the Cartesian co-ordinates of the C β of all residues.
I D, Kuntz +3 more
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1989
The polypeptide chain of globular protein is linear, but the three-dimensional of tertiary structure is quite contorted. This was apparent from the first crystallographic determination of the structure of a protein by Kendrew et al. (1960). The contortion arises because of the need to satisfy a multitude of conflicting interactions: the hydrogen ...
Fred E. Cohen, Irwin D. Kuntz
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The polypeptide chain of globular protein is linear, but the three-dimensional of tertiary structure is quite contorted. This was apparent from the first crystallographic determination of the structure of a protein by Kendrew et al. (1960). The contortion arises because of the need to satisfy a multitude of conflicting interactions: the hydrogen ...
Fred E. Cohen, Irwin D. Kuntz
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Computing tertiary structures of proteins
Journal of Protein Chemistry, 1990Using only data on sequence, a method of computing a low-resolution tertiary structure of a protein is described. The steps are: (a) Estimate the distances of individual residues from the centroid of the molecule, using data on hydrophobicity and additional geometrical constraints. (b) Using these distances, construct a two-valued matrix whose elements,
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Phylogenetics: Tertiary protein structures needed
Nature Ecology & Evolution, 2017We need to estimate protein tertiary structure, as well as using primary sequences, in order to further our understanding of protein evolution and evolutionary processes in general.
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2003
Experimental methods such as nuclear magnetic resonance spectroscopy or x-ray diffraction analysis are widely used in order to determine tertiary pro- tein structures. But the rate at which protein structures can be determined by experimental techniques is much lower than the rate at which new genes are identified by the various genome projects ...
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Experimental methods such as nuclear magnetic resonance spectroscopy or x-ray diffraction analysis are widely used in order to determine tertiary pro- tein structures. But the rate at which protein structures can be determined by experimental techniques is much lower than the rate at which new genes are identified by the various genome projects ...
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Maturation of Tertiary Lymphoid Structures
Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at localDaniel H, Shu, Dimitrios N, Sidiropoulos
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