The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase [PDF]
BMC Cancer, 2002 Background The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catalytic subunit of telomerase.
Schulze Wolfgang +8 more
doaj +4 more sources
Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report [PDF]
BMC Urology, 2004 Background Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to have low sensitivity to ...
Yanaihara Hitoshi +6 more
doaj +4 more sources
Immunotherapy in Testicular Germ Cell Tumors
Frontiers in Oncology, 2020 Testicular germ cell tumors (TGCTs) are malignancies with very high curative potential even in metastatic settings, mainly due to the introduction of cisplatin in the treatment of this disease.
Katarina Kalavska +6 more
doaj +2 more sources
Identification of 22 susceptibility loci associated with testicular germ cell tumors
Nature Communications, 2021 Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date.
John Pluta +56 more
doaj +2 more sources
Emerging Prognostic Biomarkers in Testicular Germ Cell Tumors: Looking Beyond Established Practice
Frontiers in Oncology, 2018 Testicular germ cell tumors are unique among solid cancers. Historically, this disease was deadly if progressed beyond the stage I. The implementation of cisplatin-based chemotherapy regimens has drastically changed the clinical outcome of metastatic ...
Michal Chovanec +7 more
doaj +2 more sources
PD-L1 expression in testicular germ cell tumors undergoing spontaneous regression [PDF]
Biomolecules & BiomedicineSpontaneous regression of testicular germ cell tumors is a well-known phenomenon; however, the precise mechanisms of spontaneous regression are still unknown.
Ivan Novak +8 more
doaj +2 more sources
Organ-Sparing Surgery for Testicular Germ Cell Tumors: A Current Perspective [PDF]
Medicina, 2023 Background and Objectives: We aimed to evaluate the oncological and functional outcomes of organ-sparing surgery for testicular germ cell tumors, a procedure that seeks to strike a balance between effective cancer control and organ preservation, in the ...
Esther García Rojo +11 more
doaj +2 more sources
Brachyury oncogene is a prognostic factor in high-risk testicular germ cell tumors [PDF]
Andrology, 2018 The T-box transcription factor Brachyury has been considered a cancer-specific marker and a novel oncotarget in solid tumors. Brachyury overexpression has been described in various cancers, being associated with epithelial-mesenchymal transition ...
Albany +41 more
core +2 more sources
On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer
Frontiers in Endocrinology, 2019 Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes.
Tiziano Baroni +6 more
doaj +2 more sources