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The epigenome of testicular germ cell tumors [PDF]

APMIS, 2007
Gene expression is tightly regulated in normal cells, and epigenetic changes disturbing this regulation are a common mechanism in the development of cancer. Testicular germ cell tumor (TGCT) is the most common malignancy among young males and can be classified into two main histological subgroups: seminomas, which are basically devoid of DNA ...
Guro E, Lind, Rolf I, Skotheim, Ragnhild A, Lothe   +2 more
openaire   +2 more sources

Testicular germ cell tumor genomics [PDF]

Current Opinion in Urology, 2017
Testicular germ cell tumors (TGCTs) are a model for curable cancer because of exquisite chemosensitivity and incorporation of multimodal therapy. Nevertheless, our ability to predict metastases in early-stage disease and responders to chemotherapy in advanced disease is limited. Treatment options for cisplatin-resistant disease are sparse.
Solomon L, Woldu, James F, Amatruda, Aditya, Bagrodia   +2 more
openaire   +2 more sources

Cisplatin-based chemotherapy of testicular cancer - Two decades after a major breakthrough [PDF]

, 2000
Two decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer, At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard ...
Gerl, Arthur
core   +1 more source

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. [PDF]

, 2013
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported.
Robert A Huddart, Sheila Seal, Eeles, Rosalind, Kote-Jarai, Zsofia, Elliot, Anna, Ruark, E, McDonald, Heather, Peto, Julian, D Timothy Bishop, Muir, K; id_orcid, Stratton, Michael R, Seal, Sheila, Turnbull, Clare, Kote-Jarai, Z, Muir, Kenneth (Kenneth R.), Kenneth Muir, Perdeaux, Elizabeth, Easton, Douglas F, McDonald, H, Zhang, Feng, Easton, Douglas F., Elizabeth Rapley, Muir, K, Seal, S, Janet Shipley, Perdeaux, E, Stratton, MR, Feng Zhang, KingWai Lau, Rahman, N, Huddart, RA, Bishop, DT, Rapley, Elizabeth, Rosalind Eeles, Stratton, Michael R., Huddart, Robert A, Heather McDonald, Huddart, R A, Nazneen Rahman, Muir, Kenneth, Elise Ruark, Shipley, Janet, McDonald, H. (Heather), UK Testicular Cancer Collaboration (UKTCC), Michael R Stratton, Anna Elliot, Nsengimana, J, Eeles, R, Jeremie Nsengimana, Elliot, A, Douglas F Easton, Shipley, J, UK Testicular Cancer Collaboration (UKTCC),, Turnbull, C, Elizabeth Perdeaux, Zsofia Kote-Jarai, Rapley, E. (Elizabeth), Bishop, D. Timothy (David Timothy), Clare Turnbull, Peto, J, Stratton, M R, Lau, Kingwai, Lau, K, Nsengimana, Jeremie, Ruark, Elise, Bishop, D Timothy, Easton, DF, Zhang, F, Rahman, Nazneen, Easton, D F, Rapley, E, Julian Peto, Bishop, D T, Huddart, Robert A.   +73 more
core   +1 more source

Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care

Frontiers in Cell and Developmental Biology, 2022
Testicular cancer is the most common solid tumor affecting young males. Most testicular cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) and non-seminomatous testicular germ cell tumors (NSGCTs).
Alina-Teodora Nicu, Alina-Teodora Nicu, Cosmin Medar, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Gratiela Gradisteanu Pircalabioru, Liliana Burlibasa, Liliana Burlibasa   +9 more
doaj   +1 more source

Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report

BMC Urology, 2004
Background Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to have low sensitivity to ...
Yanaihara Hitoshi, Nakagawa Ken, Mitsuhashi Tomoko, Ueno Munehisa, Kuroda Isao, Tsukamoto Takuji, Deguchi Nobuhiro   +6 more
doaj   +1 more source

The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

BMC Cancer, 2002
Background The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catalytic subunit of telomerase.
Schulze Wolfgang, Schostak Martin, Straub Bernd, Krause Hans, Müller Markus, Burger Angelika M, Schrader Mark, Lauke Heidrun, Miller Kurt   +8 more
doaj   +1 more source

Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor

IJU Case Reports, 2022
Introduction Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy.
Takashi Ueda, Ippei Takada, Teruki Shimizu, Saya Ito, Atsuko Fujihara, Takumi Shiraishi, Terukazu Nakamura, Osamu Ukimura   +7 more
doaj   +1 more source

Metastatic Potential of Small Testicular Germ Cell Tumors: Implications for Surveillance of Small Testicular Masses

European Urology Open Science, 2022
Incidental detection of urogenital tumors has increased in recent decades owing to the greater use of ultrasonography and cross-sectional imaging. For patients with low-risk prostate cancer or small renal masses, active surveillance represents a valid ...
Manolis Pratsinis, Christian Fankhauser, Katerina Pratsinis, Jörg Beyer, Emanuel Bührer, Richard Cathomas, Natalie Fischer, Thomas Hermanns, Anita Hirschi-Blickenstorfer, Jörn Kamradt, Luis Alex Kluth, Deborah Zihler, Walter Mingrone, Beat Müller, Tim Nestler, Sacha I. Rothschild, Bettina Seifert, Arnoud J. Templeton, Angelika Terbuch, Mark-Peter Ufen, Regina Woelky, Silke Gillessen, Christian Rothermundt   +22 more
doaj   +1 more source

An Overview of Testicular Germ Cell Tumors

Archives of Pathology & Laboratory Medicine, 2007
Abstract Context. —More than 90% of testicular neoplasms originate from germ cells. Testicular germ cell tumors (GCTs) are a heterogeneous group of neoplasms with diverse histopathology and clinical behavior. Objective.
Armita, Bahrami, Jae Y, Ro, Alberto G, Ayala   +2 more
openaire   +2 more sources