Results 91 to 100 of about 21,990 (240)

Context‐Dependent Roles of ANGPTL2‐Mediated Inflammaging in Tissue Homeostasis, Pathological Tissue Remodeling, and Longevity

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Yumoto et al. show that ANGPTL2 regulates inflammation, fibrosis, and tissue remodeling in high‐fat diet‐induced premature aging. ANGPTL2 deficiency shortens lifespan but reduces inflammation, revealing its context‐dependent and organ‐specific roles in maintaining homeostasis.
Shinsei Yumoto   +8 more
wiley   +1 more source

Detection of germ cell neoplasia in situ and testicular cancer risk in men with testicular microlithiasis: Real world results through 10 years

open access: yesAndrology, Volume 14, Issue 2, Page 459-465, February 2026.
Abstract Background Guidelines recommend biopsies for men <50 years with testicular microlithiasis and cancer risk factors to rule out germ cell neoplasia in situ. Limited data support this practice. Objectives To clarify the significance of testicular microlithiasis by examining pathological findings in men with testicular microlithiasis.
Karoline Skov Lundager   +7 more
wiley   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

open access: yesCancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima   +13 more
wiley   +1 more source

Alterations of the c‐kit gene in testicular germ cell tumors [PDF]

open access: hybrid, 2003
Yuji Sakuma   +4 more
openalex   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

open access: yesClinical Endocrinology, Volume 104, Issue 2, Page 92-102, February 2026.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri   +6 more
wiley   +1 more source

Molecular profile of atypical Leydig cell tumours

open access: yesHistopathology, Volume 88, Issue 3, Page 628-635, February 2026.
Copy number variations by themselves are not sufficient to discriminate between benign and potential malignant Leydig cell tumours (LCTs). Genomic instability was only detected in malignant and atypical cases, and not in any benign tumours. Currently, the presence of metastasis remains the only malignant criterion for LCTs.
Muhammad F.K. Choudhry   +6 more
wiley   +1 more source

p53 and MDM2 expression in primary and metastatic testicular germ cell tumors: Association with clinical outcome [PDF]

open access: bronze, 2020
João Lobo   +8 more
openalex   +1 more source

Clinical significance and immune microenvironment association of cuproptosis‐related genes in pan‐cancer

open access: yesExperimental Physiology, Volume 111, Issue 2, Page 539-555, 1 February 2026.
Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge   +10 more
wiley   +1 more source

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