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The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors. [PDF]

Andrology
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Kanetsky PA, Almstrup K, Cherlin S, Cortessis VK, Ferlin A, Gietema JA, González-Neira A, Grotmol T, Hamilton RJ, Haugen TB, Kiemeney LA, Kim J, Krausz C, Lessel D, Lothe RA, Nead KT, Nsengimana J, Poynter JN, Rajpert-DeMeyts E, Richiardi L, Schwartz SM, Skotheim RI, Stewart DR, Turnbull C, Wiklund F, Zheng T, Nathanson KL, McGlynn KA, Testicular Cancer Consortium.   +28 more
europepmc   +2 more sources

Retroperitoneal germ cell tumor, primary or secondary: A diagnostic conundrum

MGM Journal of Medical Sciences, 2023
Germ cell tumor, seminoma, is the most common cancer in young men’s testis. However, a small subset of tumors (1%–2%) originate in other locations and are referred to as primary extragonadal germ cell tumors. But such type of tumors’ origin is thought to
Surabhi Singh, Pranita Mohanty, Prateek Das, Debahuti Mohapatra, Pradyumna Kumar Sahoo   +4 more
doaj   +1 more source

Familial testicular germ cell tumors in two brothers

IJU Case Reports, 2020
Introduction Two percent of testicular germ cell tumors occur in family clusters. Here, we report metachronous testicular germ cell tumors in two brothers.
Senji Hoshi, Vladimir Bilim, Kiyotsugu Hoshi, Isoji Sasagawa, Kotarou Otake, Daigo Chiba, Shinta Suenaga, Masahito Konno, Yuki Katsumata, Kento Morozumi, Jun Takemoto, Kenji Numahata, Keiichi Ito   +12 more
doaj   +1 more source

Seminoma metastasized to the prostate: A case report and literature review

Urology Case Reports, 2020
The testicular seminomas are germ-cell tumors which account for approximately 50% of all testicular tumors. Most primary testicular germ cell tumors metastasize through a lymphatic system in a predictable pattern with the retroperitoneal lymph nodes ...
Ceren Durer, Isin Yagmur Comba, Seren Durer, Nancy Torres Luna, Parikh Jignesh, Allison Carilli   +5 more
doaj   +1 more source

Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival

IJU Case Reports, 2023
Introduction Testicular germ cell tumors with somatic‐type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis.
Junji Kitamura, Mitsuhiro Tambo, Ayano Nishijima, Kazuki Masuda, Jimpei Miyakawa, Yu Nakamura, Masachika Fujiwara, Takeshi Kishida, Hiroyuki Ito, Hiroshi Fukuhara   +9 more
doaj   +1 more source

Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care

Frontiers in Cell and Developmental Biology, 2022
Testicular cancer is the most common solid tumor affecting young males. Most testicular cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) and non-seminomatous testicular germ cell tumors (NSGCTs).
Alina-Teodora Nicu, Alina-Teodora Nicu, Cosmin Medar, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Gratiela Gradisteanu Pircalabioru, Liliana Burlibasa, Liliana Burlibasa   +9 more
doaj   +1 more source

Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report

BMC Urology, 2004
Background Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to have low sensitivity to ...
Yanaihara Hitoshi, Nakagawa Ken, Mitsuhashi Tomoko, Ueno Munehisa, Kuroda Isao, Tsukamoto Takuji, Deguchi Nobuhiro   +6 more
doaj   +1 more source

Bone marrow metastasis in a patient with non‐seminomatous testicular germ cell tumor

IJU Case Reports, 2022
Introduction Metastasis to the bone marrow is rare in testicular germ cell tumor patients. We report a case of a patient with a non‐seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy.
Takashi Ueda, Ippei Takada, Teruki Shimizu, Saya Ito, Atsuko Fujihara, Takumi Shiraishi, Terukazu Nakamura, Osamu Ukimura   +7 more
doaj   +1 more source

Metastatic Potential of Small Testicular Germ Cell Tumors: Implications for Surveillance of Small Testicular Masses

European Urology Open Science, 2022
Incidental detection of urogenital tumors has increased in recent decades owing to the greater use of ultrasonography and cross-sectional imaging. For patients with low-risk prostate cancer or small renal masses, active surveillance represents a valid ...
Manolis Pratsinis, Christian Fankhauser, Katerina Pratsinis, Jörg Beyer, Emanuel Bührer, Richard Cathomas, Natalie Fischer, Thomas Hermanns, Anita Hirschi-Blickenstorfer, Jörn Kamradt, Luis Alex Kluth, Deborah Zihler, Walter Mingrone, Beat Müller, Tim Nestler, Sacha I. Rothschild, Bettina Seifert, Arnoud J. Templeton, Angelika Terbuch, Mark-Peter Ufen, Regina Woelky, Silke Gillessen, Christian Rothermundt   +22 more
doaj   +1 more source

The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

BMC Cancer, 2002
Background The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catalytic subunit of telomerase.
Schulze Wolfgang, Schostak Martin, Straub Bernd, Krause Hans, Müller Markus, Burger Angelika M, Schrader Mark, Lauke Heidrun, Miller Kurt   +8 more
doaj   +1 more source