Results 21 to 30 of about 70,701 (334)

Familial testicular germ cell tumors in two brothers

IJU Case Reports, 2020
Introduction Two percent of testicular germ cell tumors occur in family clusters. Here, we report metachronous testicular germ cell tumors in two brothers.
Senji Hoshi, Vladimir Bilim, Kiyotsugu Hoshi, Isoji Sasagawa, Kotarou Otake, Daigo Chiba, Shinta Suenaga, Masahito Konno, Yuki Katsumata, Kento Morozumi, Jun Takemoto, Kenji Numahata, Keiichi Ito   +12 more
doaj   +1 more source

Genetics of testicular germ cell tumors [PDF]

Current Opinion in Urology, 2019
Understanding the molecular basis underlying testicular germ cell tumors (TGCTs) may help improve patient outcomes, particularly for patients with poorer risk or chemoresistant disease. Here, we review the major contemporary advances in elucidating TGCT genetics by discussing patterns of TGCT inheritance, recent genomic and transcriptomic discoveries ...
Aditya Bagrodia, Nirmish Singla, John T. Lafin, James F. Amatruda, Rashed Ghandour, Samuel D. Kaffenberger   +5 more
openaire   +2 more sources

The epigenome of testicular germ cell tumors [PDF]

APMIS, 2007
Gene expression is tightly regulated in normal cells, and epigenetic changes disturbing this regulation are a common mechanism in the development of cancer. Testicular germ cell tumor (TGCT) is the most common malignancy among young males and can be classified into two main histological subgroups: seminomas, which are basically devoid of DNA ...
Ragnhild A. Lothe, Rolf Inge Skotheim, Guro Elisabeth Lind   +2 more
openaire   +3 more sources

Surgical salvage in patients with advanced testicular cancer: indications, risks and outcomes [PDF]

, 2020
The purpose of this review is to present a comprehensive and updated review of the literature and summary of the indications, risks and outcomes related to salvage, desperation and late relapse surgery for advanced testicular cancer.
Cary, Clint, Masterson, Timothy A., Speir, Ryan W.   +2 more
core   +1 more source

Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives

Cancers, 2020
Testicular germ cell tumors share a marked sensitivity to cisplatin, contributing to their overall good prognosis. However, a subset of patients develop resistance to platinum-based treatments, by still-elusive mechanisms, experiencing poor quality of ...
J. Lobo, C. Jerónimo, R. Henrique
semanticscholar   +1 more source

Testicular germ cell tumor genomics [PDF]

Current Opinion in Urology, 2017
Testicular germ cell tumors (TGCTs) are a model for curable cancer because of exquisite chemosensitivity and incorporation of multimodal therapy. Nevertheless, our ability to predict metastases in early-stage disease and responders to chemotherapy in advanced disease is limited. Treatment options for cisplatin-resistant disease are sparse.
Aditya Bagrodia, Solomon L. Woldu, James F. Amatruda   +2 more
openaire   +3 more sources

Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases [PDF]

, 2017
BACKGROUND: Cytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates.
Albany, Costantine, Boyd, Thomas, Einhorn, Lawrence, Feldman, Darren R., Garbo, Lawrence, Josephson, Neil   +5 more
core   +1 more source

Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study

Journal of Clinical Oncology, 2019
PURPOSE Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable toward both seminoma and
K. Dieckmann, A. Radtke, L. Géczi, C. Matthies, P. Anheuser, Ulrike Eckardt, Jörg Sommer, F. Zengerling, E. Trenti, R. Pichler, H. Belz, S. Zastrow, A. Winter, S. Melchior, Johannes Hammel, J. Kranz, M. Bolten, S. Krege, B. Haben, W. Loidl, C. Ruf, J. Heinzelbecker, A. Heidenreich, J. Cremers, C. Oing, T. Hermanns, C. Fankhauser, S. Gillessen, Hermann Reichegger, R. Cathomas, M. Pichler, M. Hentrich, K. Eredics, A. Lorch, C. Wülfing, S. Peine, W. Wosniok, C. Bokemeyer, G. Belge   +38 more
semanticscholar   +1 more source

Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival

IJU Case Reports, 2023
Introduction Testicular germ cell tumors with somatic‐type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis.
Junji Kitamura, Mitsuhiro Tambo, Ayano Nishijima, Kazuki Masuda, Jimpei Miyakawa, Yu Nakamura, Masachika Fujiwara, Takeshi Kishida, Hiroyuki Ito, Hiroshi Fukuhara   +9 more
doaj   +1 more source

Cisplatin-based chemotherapy of testicular cancer - Two decades after a major breakthrough [PDF]

, 2000
Two decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer, At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard ...
Gerl, Arthur
core   +1 more source