Results 51 to 60 of about 312,372 (339)

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Testosterone increases the virulence traits of uropathogenic Escherichia coli

Frontiers in Microbiology
Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections (UTIs) in humans. Testosterone negatively impacts UTIs by affecting the immune response, leading to higher susceptibility of chronic cystitis in individuals with ...
Rongrong Wu, Carolina Pettersson, Carolina Pettersson, Isak Demirel   +3 more
doaj   +1 more source

Current Routine Testosterone Immunoassays Are Unsuitable for Lowering the General Castration Cutoff Recommendation to <0.7 nmol/l (20 ng/dl)

European Urology Open Science, 2023
Testosterone measurements are essential in the management of patients with prostate cancer undergoing castration and androgen deprivation therapy. There has been an ongoing discussion on the testosterone castration cutoff (TCC), with the primary focus on
Huub H. van Rossum, Lennart J. van Winden, Andries M. Bergman, Henk G. van der Poel   +3 more
doaj  

Testosterone Therapy with a Man with Equivocal Testosterone Levels

The Journal of Sexual Medicine, 2022
the paper describes a testosterone therapy with a man with equivocal testosterone ...
Corona, Giovanni, Maggi, Mario
openaire   +2 more sources

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Two Transgender Men Receiving Subdermal Testosterone Pellets for Gender Affirmation

AACE Clinical Case Reports, 2023
Background/Objective: Testosterone treatment is employed in transgender men to help them affirm their gender. Our objective is to report the cases of 2 transgender men who received subdermal testosterone pellets as the mode of testosterone administration.
Sune L. Wolf Pulsiano, M3, Jenna L. Sarvaideo, DO   +1 more
doaj  

Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels.

Journal of the American Medical Association (JAMA), 2013
IMPORTANCE Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown.
R. Vigen, Colin I. O’Donnell, A. Baron, G. Grunwald, T. Maddox, S. Bradley, A. Barqawi, Glenn Woning, M. Wierman, M. Plomondon, J. Rumsfeld, P. Ho   +11 more
semanticscholar   +1 more source

Testosterone and the Heart [PDF]

Methodist DeBakey Cardiovascular Journal, 2017
Testosterone (T) has a number of important effects on the cardiovascular system. In men, T levels begin to decrease after age 40, and this decrease has been associated with an increase in all-cause mortality and cardiovascular (CV) risk. Low T levels in men may increase their risk of developing coronary artery disease (CAD), metabolic syndrome, and ...
Travis Goodale, Richard J. Robbins, Archana R. Sadhu, Steven M. Petak   +3 more
openaire   +2 more sources

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Falsely elevated serum testosterone measurements resulting from testosterone topical gel contamination of the venipuncture site: Case Series and retrospective review

Heliyon, 2023
Testosterone as replacement therapy for male hypogonadism or as gender-affirming hormone therapy for transgender and non-binary patients has increased worldwide.
Aranza Pinedo Pichilingue, Dina N. Greene, Matthew D. Krasowski   +2 more
doaj