Results 21 to 30 of about 92,143 (259)

Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells

OncoImmunology, 2019
We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi, Angelika Holler, Pedro Velica, Gavin Bendle, Hans J. Stauss   +4 more
doaj   +1 more source

DNA methylation aberrancies as a guide for surveillance and treatment of human cancers

Epigenetics, 2017
DNA methylation aberrancies are hallmarks of human cancers and are characterized by global DNA hypomethylation of repetitive elements and non-CpG rich regions concomitant with locus-specific DNA hypermethylation.
Gangning Liang, Daniel J. Weisenberger
doaj   +1 more source

Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China

Frontiers in Microbiology, 2018
To investigate tetracycline resistance and resistant genotype in Riemerella anatipestifer, the tetracycline susceptibility of 212 R. anatipestifer isolates from China between 2011 and 2017 was tested.
De-Kang Zhu, De-Kang Zhu, Hong-Yan Luo, Hong-Yan Luo, Ma-Feng Liu, Ma-Feng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Ren-Yong Jia, Ren-Yong Jia, Shun Chen, Shun Chen, Kun-Feng Sun, Kun-Feng Sun, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Xiao-Yue Chen, Xiao-Yue Chen, An-Chun Cheng, An-Chun Cheng, Ming-Shu Wang, Ming-Shu Wang   +23 more
doaj   +1 more source

A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance

Hepatology Communications, EarlyView., 2022
Abstract Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed.
Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke de Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Mariëlle M. E. Coolsen, Peter van Duijvendijk, Joris I. Erdmann, Paul Gobardhan, Robbert J. de Haas, Tjarda van Heek, Hwai‐Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Türkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. te Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn I. Buis, Joost M. Klaase, Koert P. de Jong, Vincent E. de Meijer, the Dutch Benign Liver Tumor Group, R. B. Takkenberg, J. Verheij, O. M. van Delden, J. I. Erdmann, B. V. van Rosmalen, A. Furumaya, G. Kazemier, D. Ramsoekh, J. N. M. IJzermans, R. A. de Man, M. D. Doukas, M. G. Thomeer, A. J. Klompenhouwer, A. F. M. Schaapherder, M. E. Tushuizen, M. J. Coenraad, A. S. L. P. Crobach, M. C. Burgmans, S. Feshtali, M. M. E. Coolsen, M. Kramer, J. C. Beckervordersandforth, I. V. Samarska, C. van der Leij, R. Miclea, J. H. W. de Wilt, P. B. van den Boezem, E. T. T. L. Tjwa, I. Munsterman, S. Vos, S. van Koeverden, V. E. de Meijer, F. J. C. Cuperus, R. J. de Haas, E. W. Duiker, M. P. D. Haring   +70 more
wiley   +1 more source

Characterization of two multidrug-resistant Klebsiella pneumoniae harboring tigecycline-resistant gene tet(X4) in China

Frontiers in Microbiology, 2023
ObjectivesTigecycline is recognized as one of the last-line antibiotics to treat serious bacterial infection caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The plasmid-borne gene tet(X4) mediates high resistance to tigecycline. However, the
Yanxian Yang, Yanxian Yang, Yanxian Yang, Ruowen He, Ruowen He, Ruowen He, Ruowen He, Yiping Wu, Yiping Wu, Yiping Wu, Mingyang Qin, Mingyang Qin, Jieyun Chen, Jieyun Chen, Jieyun Chen, Yu Feng, Yu Feng, Yu Feng, Runping Zhao, Lei Xu, Xilong Guo, Xilong Guo, Xilong Guo, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Min Dai, Bin Yan, Bin Yan, Bin Yan, Li-Na Qin, Li-Na Qin   +31 more
doaj   +1 more source

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aim of this study was to characterise a novel tet(X6)-carrying plasmid detected in a livestock-associated Acinetobacter towneri isolate.
Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +7 more
doaj   +1 more source

Detection and Diversity evaluation of tetracycline resistance genes in grassland-based production systems in Colombia, South America

Frontiers in Microbiology, 2011
Grassland-based production systems use approximately 26 percent of land surface on earth. However, there are no evaluations of these systems as a source of antibiotic pollution.
Johanna eSantamaría, Liliana eLópez, Carlos Yesid Soto   +2 more
doaj   +1 more source

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria

mSystems, 2020
The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile tet(X) variants were reported in diverse pathogens from different sources.
Ruichao Li, Xiaoyu Lu, Kai Peng, Ziyi Liu, Yan Li, Yuan Liu, Xia Xiao, Zhiqiang Wang   +7 more
doaj   +1 more source

Prevalence and risk factors of tet(X4)-positive Enterobacteriaceae in human gut microbiota

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This work is aimed to investigate the prevalence of tet(X4) in healthy individuals and patients and assess risk factors associated with tet(X4)-positive populations.
Yu Zeng, Li Deng, Xianyuan Zhou, Chi Zhang, Zhen Hu, Yunsheng Chen, Weidong Zheng   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source