Results 111 to 120 of about 305,776 (233)

Whole Genome Sequencing in Prenatal Diagnostics: The Danish Approach to Guideline Formation and Implementation Within Public Healthcare

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the implementation of whole genome sequencing (WGS) in prenatal diagnostics and outline the national guideline system facilitating this. Methods Clinical guidelines for WGS in prenatal diagnostics were developed and implemented by the Danish Fetal Medicine Society.
Ida Vogel, Lotte Andreasen, Marie Balslev‐Harder, Naja Becher, Anja Ernst, Kasper Gadsbøll, Tina Duelund Hjortshøj, Marie Skov Hvidbjerg, Martin Larsen, Stina Lou, Ida Charlotte Bay Lund, Lars Henning Pedersen, Laura Kirstine Sønderberg Roos, Lene Sperling, Lone Sunde, Pernille Mathiesen Tørring, Cathrine Vedel, Olav Bjørn Petersen   +17 more
wiley   +1 more source

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

Aspects of Discrete Breathers and New Directions

, 2001
We describe results concerning the existence proofs of Discrete Breathers (DBs) in the two classes of dynamical systems with optical linear phonons and with acoustic linear phonons.
A Bikaki, AA Ovchinnikov, AJ Sievers, G Kopidakis, G Kopidakis, GL Lamb, GP Tsironis, J-A Sepulchre, JL Marin, K0 Rasmussen, KO Rasmussen, L Landau, R Livi, R Papoular, RS MacKay, RS MacKay, RT Birge, S Aubry, S Aubry, S Flach   +19 more
core   +3 more sources

Analysis of the influence of supplementary reinforcement on the behavior of reinforced‐concrete two‐pile caps subjected to concentric and eccentric loading

Structural Concrete, EarlyView.
Abstract This article examines the behavior of reinforced‐concrete pile caps on two piles under concentric and eccentric loading, with emphasis on the influence of horizontal and vertical supplementary reinforcement on load‐carrying capacity. Although the Strut‐and‐Tie method does not include this reinforcement in the internal equilibrium, it was found
Marcio Ferreira Cardoso, Ricardo de Paula Randi, Thomaz Eduardo Teixeira Buttignol, Luiz Carlos de Almeida, Leandro Mouta Trautwein   +4 more
wiley   +1 more source

Emergence of transferable tigecycline and eravacycline resistance gene tet(X4) in Escherichia coli isolates from Iran

Scientific Reports
Tigecycline (TGC) and eravacycline (ERV) are critical last-resort antibiotics used to treat complicated infections caused by extensively drug-resistant Gram-negative bacteria particularly carbapenem- and colistin-resistant Enterobacterales.
Mehri Haeili, Mahdi Aghajanzadeh, Kiarash Moghaddasi, Maryam Omrani, Arash Ghodousi, Daniela Maria Cirillo   +5 more
doaj   +1 more source

Linguistic Evidence Suggests that Xiōng‐nú and Huns Spoke the Same Paleo‐Siberian Language

Transactions of the Philological Society, EarlyView.
Abstract The Xiōng‐nú were a tribal confederation who dominated Inner Asia from the third century BC to the second century AD. Xiōng‐nú descendants later constituted the ethnic core of the European Huns. It has been argued that the Xiōng‐nú spoke an Iranian, Turkic, Mongolic or Yeniseian language, but the linguistic affiliation of the Xiōng‐nú and the ...
Svenja Bonmann, Simon Fries
wiley   +1 more source

Spread of tetracycline resistance genes at a conventional dairy farm

Frontiers in Microbiology, 2015
The use of antibiotics in animal husbandry contributes to the worldwide problem of increasing antibiotic resistance in animal and human pathogens. Intensive animal production is considered an important source of antibiotic resistance genes released to ...
Martina eKyselkova, Jiri eJirout, Nadezda eVrchotova, Heike eSchmitt, Dana eElhottova   +4 more
doaj   +1 more source

The transformer gene controls sexual development in Drosophila suzukii

Insect Science, EarlyView.
The transformer gene plays a key role in the genetic pathway for sexual development in Drosophila suzukii Abstract The genetic network of sex determination in the model organism Drosophila melanogaster was investigated in great detail. Such knowledge not only advances our understanding of the evolution and regulation of sexual dimorphism in insects ...
Ying Yan, Jing Zhao, Jonas Schwirz, Cristina Borghesi, Conghui Liu, Bo Liu, Wanqiang Qian, Fanghao Wan, Marc F. Schetelig   +8 more
wiley   +1 more source

Impact of Vegetative Treatment Systems on Multiple Measures of Antibiotic Resistance in Agricultural Wastewater [PDF]

, 2018
Wastewater is an important vector of antibiotic resistant bacteria and antibiotic resistance genes (ARB/G). While there is broad agreement that ARB/G from agricultural (ag) wastewaters can be transported through the environment and may contribute to ...
Durso, Lisa M., Henry, Christopher G., Miller, Daniel N.   +2 more
core   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source