Results 121 to 130 of about 54,144 (166)

Style‐Constrained Inverse Design of Microstructures With Tailored Mechanical Properties Using Unconditional Diffusion Models

International Journal for Numerical Methods in Engineering, Volume 127, Issue 13, 15 July 2026.
ABSTRACT Deep generative models, particularly denoising diffusion models, have achieved remarkable success in high‐fidelity generation of architected microstructures with desired properties and styles. However, these recent methods typically rely on conditional training mechanisms that require extensive labeled data.
Weipeng Xu, Ziyuan Xie, Haoju Lin, Xinyu Wang, Guangjin Mou, Tianju Xue   +5 more
wiley   +1 more source

Specific Deletion of Interleukin‐1 Beta in Microglia Improves Acute Outcome and Modulates Neurogenesis After Ischemic Stroke

Glia, Volume 74, Issue 7, July 2026.
Microglial IL‐1β deletion improves acute outcome and reduces neutrophil recruitment after experimental ischemic stroke. Microglial IL‐1β deletion increases neurogenesis in the subventricular zone after experimental ischemic stroke. ABSTRACT Interleukin‐1 (IL‐1) signaling is a major driver of post‐ischemic neuroinflammation, yet the cell‐ and isoform ...
Alba Grayston, Margarida Baptista, Kelly Wemyss, Ruby Taylor, Grace Cullen, Syeda S. Jafree, Nadim Luka, Joshua R. Cox, Joanne E. Konkel, David Brough, Stuart M. Allan, Emmanuel Pinteaux   +11 more
wiley   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real‐World Data Screening and in Vitro Validation

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Drug repositioning analysis identifies candidate therapeutic agents for Alzheimer’s diseaseand supports further mechanistic and translational investigation. ABSTRACT Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval.
Sho Sakagami, Yuya Yoshida, Shota Uemura, Taisei Kumamoto, Ryotaro Tsukamoto, Takumi Nishi, Shimpei Kawano, Kohei Fukuoka, Hanami Ino, Kengo Hamamura, Shigehiro Ohdo, Naoya Matsunaga   +11 more
wiley   +1 more source

A General Strategy for the Synthesis of Jerangolids Enabled by π‐allyl Stille Coupling

Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
A general strategy for the synthesis of jerangolids is established, featuring a late‐stage π‐allyl Stille coupling of two advanced, highly customizable building blocks to form the skipped diene core. The approach provides access to all naturally occurring jerangolids, including jerangolid H, whose configuration is confirmed by NMR analysis.
Janick Schug, Bernd Morgenstern, Johann Jauch   +2 more
wiley   +1 more source

Emergence of Plasmid-Mediated Resistance Genes tet(X) and mcr-1 in Escherichia coli Clinical Isolates from Pakistan. [PDF]

mSphere, 2021
Li R, Mohsin M, Lu X, Abdullah S, Munir A, Wang Z.   +5 more
europepmc   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

Delamination of Vermiculite into Ultrahigh‐Aspect‐Ratio Nanosheets

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 9, 3 June 2026.
Efficient ion exchange allows for thermodynamically driven delamination of vermiculite into high‐aspect ratio nanosheets. The applicability of sustainable materials in the packaging industry is currently limited by the poor gas barrier performance of most biodegradable polymers.
Felix Uhlig, Alexander M. Stich, Kevin Hagmann, Sabine Rosenfeldt, Josef Breu   +4 more
wiley   +1 more source

Reactivity of the Iron Complexes with the Macrocyclic Ligand 5,5,7,12,12,14‐Hexamethyl‐1,4,8,11‐Tetraazacyclotetradecane (tet) Toward Dioxygen

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 9, 3 June 2026.
The complex [(tet a)FeII(OTf)2] reacts with dioxygen first to a superoxido intermediate and in a consecutive reaction to the corresponding iron–oxido complex. The reactions of the iron complexes [(tet a)FeII(OTf)2] and [(tet b)FeII](OTf)2 (tet = 5,5,7,12,12,14‐hexamethyl‐1,4,8,11‐tetraazacyclotetradecane) with dioxygen were investigated.
Kevin Keller, Jakob Möbs, Siegfried Schindler   +2 more
wiley   +1 more source

A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying bla_NDM-4, tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline. [PDF]

mSphere, 2021
Hirabayashi A, Dao TD, Takemura T, Hasebe F, Trang LT, Thanh NH, Tran HH, Shibayama K, Kasuga I, Suzuki M.   +9 more
europepmc   +1 more source