Results 141 to 150 of about 7,006 (230)

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. [PDF]

, 2015
BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins.
Ciuffi, A., Gawanbacht, A., Götz, N., Heilmann, J., Hotter, D., Kirchhoff, F., Kluge, S.F., Krapp, C., Mack, K., McLaren, P.J., Munoz, M., Perreaud, J., Pyndiah, N., Rausell, A., Sauter, D., Telenti, A., Thompson, D.   +16 more
core   +2 more sources

HIV vaccination: Navigating the path to a transformative breakthrough—A review of current evidence

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aim Human immunodeficiency virus (HIV) remains a significant global health challenge, with approximately 39 million people living with HIV worldwide as of 2022. Despite progress in antiretroviral therapy, achieving the UNAIDS “95‐95‐95” target to end the HIV epidemic by 2025 faces challenges, particularly in sub‐Saharan Africa ...
Godfred Yawson Scott, Dominic Worku
wiley   +1 more source

HIV-1 assembly in macrophages. [PDF]

, 2010
International audienceThe molecular mechanisms involved in the assembly of newly synthesized Human Immunodeficiency Virus (HIV) particles are poorly understood.
Philippe Benaroch, Elisabeth Billard, Raphaël Gaudin, Michael Schindler, Mabel Jouve, S Gartner, JM Orenstein, N Sharova, F Gonzalez-Scarano, PJ Ellery, S Gordon, RM Steinman, HE Gendelman, G Raposo, A Pelchen-Matthews, D Gheysen, EO Freed, PD Bieniasz, A Ono, BK Ganser-Pornillos, KC Klein, OW Lindwasser, MV Nermut, D Muriaux, IB Hogue, E Poole, D Molle, J Jin, M Lehmann, B McDonald, N Van Damme, N Van Damme, SJ Neil, SJ Neil, M Schindler, RS Mitchell, B Mangeat, K Sato, CS Adamson, Z Mujawar, EV Ryzhova, N Mayran, M Batonick, M Boge, R Byland, G Camus, H Ohno, S Wyss, X Dong, A Joshi, S Lopez-Verges, M Nishi, JJ Leblanc, A Ryo, Y Tang, NW Martinez, E Chertova, R König, H Zhou, AL Brass, ML Yeung, FD Bushman, K Kok, JA Briggs, K Gousset, B Kramer, S Welsch, JM Orenstein, S Welsch, M Jouve, DG Nguyen, A Ono, S Nydegger, B Grigorov, NM Sherer, M Perlman, A Joshi, J Ongradi, N Jouvenet, V Marechal, K Harila, M Deneka, MA Hayat, JH Luft, AE Bennett, AA Waheed, E Ruiz-Mateos, H Chen, M Sachse, HS Kruth, JW Balliet, S Swingler, N Jouvenet, W Hubner, M Ostrowski, F Groot, S Sowinski, ML Yeung, ML Yeung, R Triboulet, L Houzet, X Wang, E Betzig   +102 more
core   +4 more sources

A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.

PLoS Pathogens, 2012
The HIV-1 accessory protein Vpu counteracts tetherin (BST-2/CD317) by preventing its incorporation into virions, reducing its surface expression, and ultimately promoting its degradation.
Tonya Kueck, Stuart J D Neil
doaj   +1 more source

Spring Symposium 2018 poster on Tetherin

, 2018
Poster showing first results of analysis of simulation data on ...
Berndsen, Christopher, Roy, Ian, Sutton, Camden   +2 more
openaire   +1 more source

Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells.

PLoS Pathogens, 2014
Bst-2/Tetherin inhibits the release of HIV by tethering newly formed virus particles to the plasma membrane of infected cells. Although the mechanisms of Tetherin-mediated restriction are increasingly well understood, the biological relevance of this ...
Sebastian Giese, Mark Marsh
doaj   +1 more source

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]

, 2015
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly.
Balasubramaniam, Balla, Benaroch, Bennett, Berditchevski, Blott, Booth, Buchacher, Bussolino, Carolina Jancic, Carr, Catalina von Bilderling, Catarina Ferreira Moita, Checkley, Chen, Chesebro, Chu, Claudia Banchio, Cox, Deneka, Desnos, Dimitrov, Dong, Doughman, Eric O. Freed, Gabriel Duette, Genevieve de Saint Basile, Gould, Grigorov, Guo, Hammond, Hogue, Hume, Imai, Jolly, Jolly, Jorge Geffner, Joshi, Jouve, Jović, Kang, Kerviel, Krementsov, Krementsov, Li, Lloyd, Lorena Sigaut, Luciana Paoletti, Luis Ferreira Moita, Lía I. Pietrasanta, Manders, Matías Ostrowski, Mercedes Cabrini, Micucci, Minogue, Mlcochova, Moffat, Monde, Ménasché, Ménasché, Nakatsu, Naldini, Ono, Ostrowski, Pan, Pehuén Pereyra Gerber, Philippe Benaroch, Pizarro-Cerdá, Popovic, Raposo, Raposo, Ruiz-Mateos, Salazar, Satoh, Schindler, Sebastian Amigorena, Sibarita, Sundquist, Théry, Trkola, Tsuboi, Tsuboi, Vickers, Villalta, Várnai, Wang, Wei, Welsch, Yauch   +88 more
core   +1 more source

Alpha interferon restricts human T-lymphotropic virus type 1 and 2 De Novo infection through PKR activation [PDF]

, 2013
International audienceType I interferon (IFN-I) inhibits the replication of different viruses. However, the effect of IFN-I on the human T-lymphotropic virus type 1 (HTLV-1) viral cycle is controversial.
Alais, Sandrine, Cachat, Anne, Chevalier, Sebastien Alain, Dutartre, Helene, Journo, Chloe, Ko, Nga Ling, Mahleux, Renaud, Ratner, Lee   +7 more
core   +4 more sources

Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.

PLoS ONE, 2011
Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. The HIV-1 accessory protein Vpu can efficiently antagonize this restriction.
Mingyu Lv, Jiawen Wang, Xiaodan Wang, Tao Zuo, Yingzi Zhu, Wei Kong, Xianghui Yu   +6 more
doaj   +1 more source

HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.

Cell, 2018
The HIV accessory protein Nef counteracts immune defenses by subverting coated vesicle pathways. The 3.7 Å cryo-EM structure of a closed trimer of the clathrin adaptor AP-1, the small GTPase Arf1, HIV-1 Nef, and the cytosolic tail of the restriction ...
Kyle L. Morris, C. Buffalo, C. Stürzel, E. Heusinger, F. Kirchhoff, X. Ren, J. Hurley   +6 more
semanticscholar   +1 more source