Results 131 to 140 of about 7,006 (230)

Innate sensing of retroviral assembly by tetherin [PDF]

Retrovirology, 2013
Tetherin/BST2 is a host antiviral membrane protein that restricts the release of diverse enveloped viruses from infected cells. In the case of primate lentiviruses, virally encoded countermeasures antagonize tetherin function, promoting nascent virion release. The ability of these countermeasures to adapt to different primate species’ tetherins appears
openaire   +1 more source

Inhibition of Lassa and Marburg Virus Production by Tetherin [PDF]

Journal of Virology, 2009
ABSTRACT Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation ...
Toshie, Sakuma, Takeshi, Noda, Shuzo, Urata, Yoshihiro, Kawaoka, Jiro, Yasuda   +4 more
openaire   +2 more sources

Unveiling the promise: Exosomes as game‐changers in anti‐infective therapy

Exploration, Volume 4, Issue 5, October 2024.
A comprehensive review to reveal new insights into exosomes’ distinctiveness, the growing availability of new analytical tools that drive the development of next‐generation synthetic systems were presented. Herein, light is shed on exosomes as drug delivery vehicles in anti‐infective therapy.
Vivek P. Chavda, Guanghong Luo, Rajashri Bezbaruah, Tutumoni Kalita, Anupam Sarma, Gitima Deka, Yanhong Duo, Bhrigu Kumar Das, Yesha Shah, Humzah Postwala   +9 more
wiley   +1 more source

CRISPR-mediated activation of endogenous BST-2/tetherin expression inhibits wild-type HIV-1 production

Scientific Reports, 2019
The CRISPR technology not only can knock out target genes by using the RNA-guided Cas9 nuclease but also can activate their expression when a nuclease-deficient Cas9 (dCas9) is employed.
Yan-Zhong Zhang, S. Ozono, Weitong Yao, M. Tobiume, S. Yamaoka, S. Kishigami, H. Fujita, K. Tokunaga   +7 more
semanticscholar   +1 more source

The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release

Journal of Biological Chemistry, 2020
Host proteins with antiviral activity have evolved as first-line defenses to suppress viral replication. The HIV-1 accessory protein viral protein U (Vpu) enhances release of the virus from host cells by down-regulating the cell-surface expression of the
A. Waheed, Maya Swiderski, Ali G Khan, Ariana Gitzen, Ahlam Majadly, E. Freed   +5 more
semanticscholar   +1 more source

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]

, 2020
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara, Fisch, Kathleen M, Kurabi, Arwa, Nasamran, Chanond A, Pak, Kwang, Ryan, Allen F, Webster, Nicholas   +6 more
core  

Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species [PDF]

, 2009
In this study, we first demonstrate that endogenous hBST-2 is predominantly expressed on the plasma membrane of a human T cell line, MT-4 cells, and that Vpu-deficient HIV-1 was less efficiently released than wild-type HIV-1 from MT-4 cells. In addition,
Kei Sato, Seiji P Yamamoto, Naoko Misawa, Takeshi Yoshida, Takayuki Miyazawa, Yoshio Koyanagi   +5 more
core   +1 more source

Milk‐derived exosomes in the regulation of nutritional and immune functions

Food Science &Nutrition, Volume 12, Issue 10, Page 7048-7059, October 2024.
Milk‐derived exosomes (MDEs), which are diminutive vesicular entities harboring diverse bioactive constituents, have been demonstrated to exert a significant influence on nutrition and immune function regulation. The constituents of MDEs possess the ability to suppress inflammatory responses, fortify the integrity of the intestinal barrier, mitigate ...
Hui Yang, Tana Wuren, Bin‐tao Zhai, Yang Liu, Demtu Er   +4 more
wiley   +1 more source

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Clinical glycoproteomics: methods and diseases

MedComm, Volume 5, Issue 10, October 2024.
An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang, Kaixin Lei, Lijun Zhao, Yong Zhang   +3 more
wiley   +1 more source