Results 121 to 130 of about 7,006 (230)
In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts
Medical Sciences, 2019 Tetherin, an interferon-induced host protein encoded by the bone marrow stromal antigen 2 (BST2/CD317/HM1.24) gene, is involved in obstructing the release of many retroviruses and other enveloped viruses by cross-linking the budding virus particles to ...
Patil Sneha +2 more
doaj +1 more source
Skin immunity and inflammation: cellular interactions and communication
Clinical &Translational Immunology, Volume 14, Issue 11, 2025.The skin is a vital organ that protects organisms from external insults, providing a barrier to the outside environment. This review provides a comprehensive overview of skin immunology and how skin immune homeostasis is maintained through cellular interactions and communication with an example of psoriasis.
Divyaa Narayanan +2 more
wiley +1 more source
Viral Takeover of the Host Ubiquitin System [PDF]
, 2011 Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) protein to substrates has been shown to govern countless cellular ...
Jean K. Gustin +3 more
core +1 more source
Origins and Evolution of tetherin , an Orphan Antiviral Gene [PDF]
Cell Host & Microbe, 2016 Tetherin encodes an interferon-inducible antiviral protein that traps a broad spectrum of enveloped viruses at infected cell surfaces. Despite the absence of any clearly related gene or activity, we describe possible scenarios by which tetherin arose that exemplify how protein modularity, evolvability, and robustness can create and preserve new ...
Daniel, Blanco-Melo +2 more
openaire +2 more sources
The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
doaj +1 more source
Resilience of BST-2/Tetherin structure to single amino acid substitutions [PDF]
PeerJ, 2019 Human tetherin, also known as BST-2 or CD317, is a dimeric, extracellular membrane-bound protein that consists of N and C terminal membrane anchors connected by an extracellular domain.
Ian R. Roy +2 more
doaj +2 more sources
Journal of Virology, 2020 The HIV-1 accessory protein Vpu enhances viral spread by downregulating CD4 and BST-2/tetherin on the surface of infected cells. Natural variability in these Vpu functions may contribute to HIV-1 pathogenesis, but this has not been investigated among the
G. Umviligihozo +18 more
semanticscholar +1 more source
Applicability of AlphaFold2 in the modeling of dimeric, trimeric, and tetrameric coiled‐coil domains
Protein Science, Volume 34, Issue 1, January 2025.Abstract Coiled coils are a common protein structural motif involved in cellular functions ranging from mediating protein–protein interactions to facilitating processes such as signal transduction or regulation of gene expression. They are formed by two or more alpha helices that wind around a central axis to form a buried hydrophobic core.
Rafal Madaj +4 more
wiley +1 more source
Human Mutation, Volume 2025, Issue 1, 2025.Background Epithelial ovarian cancer (EOC) ranks as the most lethal of gynecological cancers. Despite advances in therapeutic interventions that have marginally extended survival rates, the early detection and management of EOC pose significant hurdles.
Limin Zhang +7 more
wiley +1 more source
Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (BST-2)
DNA and Cell Biology, 2019 Host response to viral infection is a highly regulated process involving engagement of various host factors, cytokines, chemokines, and stimulatory signals that pave the way for an antiviral immune response.
Ritudhwaj Tiwari +3 more
semanticscholar +1 more source