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The history of the tetracyclines
Annals of the New York Academy of Sciences, 2011The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives over the course of more than 60 years. Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948.
Mark L, Nelson, Stuart B, Levy
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Medical Clinics of North America, 1982
Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended.
B A, Cunha, J B, Comer, M, Jonas
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Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended.
B A, Cunha, J B, Comer, M, Jonas
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Clinics in Dermatology, 2003
T etracylines were introduced in clinical medicine back in 1948 with their first representative, chlortetracycline. They show a broad spectrum of activity, can be used via many routes of administration, and are relatively safe. During the last 55 years, many facts have come to light revealing the positive and negative effects of tetracyclines, both ...
Nikolai, Tsankov +2 more
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T etracylines were introduced in clinical medicine back in 1948 with their first representative, chlortetracycline. They show a broad spectrum of activity, can be used via many routes of administration, and are relatively safe. During the last 55 years, many facts have come to light revealing the positive and negative effects of tetracyclines, both ...
Nikolai, Tsankov +2 more
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Mayo Clinic Proceedings, 1999
The tetracyclines, among the first of the antibiotics to become available 50 years ago, remain widely used. Tetracyclines have bacteriostatic activity against a wide variety of pathogens that are responsible for many common and some exotic infections.
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The tetracyclines, among the first of the antibiotics to become available 50 years ago, remain widely used. Tetracyclines have bacteriostatic activity against a wide variety of pathogens that are responsible for many common and some exotic infections.
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Obstetrics and Gynecology Clinics of North America, 1992
The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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Journal of the American Chemical Society, 2005
We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Mark G, Charest +2 more
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We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Mark G, Charest +2 more
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Cellular and Molecular Life Sciences, 2009
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Maulik, Thaker +2 more
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Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Maulik, Thaker +2 more
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Gel chromatography of tetracycline and derivatives of tetracycline
Journal of Chromatography A, 1968Abstract The elution characteristics of tetracycline (TC), anhydrotetracycline (ATC) and 4- epi -anhydrotetracycline (EATC) were studied on Sephadex gel under various conditions of pH and salt concentration. The adsorption of the compounds was strong in acid solvents but diminished as the pH was elevated.
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Oral Surgery, Oral Medicine, Oral Pathology, 1969
Abstract Tumors induced in hamsters were examined at various times following single intraperitoneal tetracycline injections. The distribution of tetracycline fluorescence in the tumor was found to vary with time in such a way as to permit the resolution of two distinct patterns, transitory and permanent.
T, Iida, E, Gassner, F S, Sayegh
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Abstract Tumors induced in hamsters were examined at various times following single intraperitoneal tetracycline injections. The distribution of tetracycline fluorescence in the tumor was found to vary with time in such a way as to permit the resolution of two distinct patterns, transitory and permanent.
T, Iida, E, Gassner, F S, Sayegh
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Neuroprotection by tetracyclines
Trends in Pharmacological Sciences, 2004The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines.
María, Domercq, Carlos, Matute
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