Results 31 to 40 of about 23,156 (257)

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundRheumatoid arthritis is a systemic inflammatory condition associated with increased cardiovascular risk that may be due to underlying endothelial dysfunction and subsequent aortic stiffening.
Kaisa M. Mäki‐Petäjä, Lisa Day, Joseph Cheriyan, Frances C. Hall, Andrew J. K. Östör, Nicholas Shenker, Ian B. Wilkinson   +6 more
doaj   +1 more source

The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders [PDF]

, 2016
INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases ...
Cortès-Saladelafont, Elisenda, Fernández-Ramos, Joaquín A, Friedman, Jennifer, Garcia-Cazorla, Àngels, Honzik, Tomas, Horvath, Gabriella, International Working Group on Neurotransmitter related disorders (iNTD), Jeltsch, Kathrin, Jung-Klawitter, Sabine, Kurian, Manju A, Kuseyri, Oya, Lopez-Laso, Eduardo, Mastrangelo, Mario, Opladen, Thomas, Pearson, Toni, Pons, Roser, Scholl-Bürgi, Sabine, Wassenberg, Tessa   +17 more
core   +4 more sources

AGMO Inhibitor Reduces 3T3-L1 Adipogenesis

Cells, 2021
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids.
Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Hofmann, Ernst R. Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder   +13 more
doaj   +1 more source

Tetrahydrobiopterin Biosynthesis in Man [PDF]

, 1986
published
Curtius, Hans-Christoph, Takikawa, Shin-Ichiro, Niederwieser, Alois, Ghisla, Sandro   +3 more
openaire   +2 more sources

Biopterin metabolism and nitric oxide recoupling in cancer

Frontiers in Oncology
Tetrahydrobiopterin is a cofactor necessary for the activity of several enzymes, the most studied of which is nitric oxide synthase. The role of this cofactor-enzyme relationship in vascular biology is well established.
Gene Chatman Clark, Gene Chatman Clark, Alan Lai, Aashri Agarwal, Zheng Liu, Zheng Liu, Xiang-Yang Wang, Xiang-Yang Wang, Xiang-Yang Wang   +8 more
doaj   +1 more source

Tetrahydrobiopterin Regulates L-tyrosine-induced Elevation of Cytosolic Calcium Concentration in Insulin-secreting Cells

Pteridines, 2006
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction [PDF]

, 2016
Ischaemic heart disease and cerebrovascular disease are the leading causes of morbidity and mortality in the world. The underlying progression of the disease is linked to a reduction in the bioavailability of nitric oxide. One factor contributing to this
Cerrato, Ruha
core   +1 more source

Biosynthesis of tetrahydrobiopterin in man [PDF]

Journal of Inherited Metabolic Disease, 1985
AbstractThe biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. The phosphate‐eliminating enzyme (PEE) was purified ~750‐fold. The conversion of NH2P3 to BH4 was catalyzed by this enzyme in the presence of partially purified sepiapterin reductase, Mg2+ and NADPH.
Curtius, Hans-Christoph, Heintel, Dorothee, Kuster, Thomas, Leimbacher, Walter, Niederwieser, Alois, Ghisla, Sandro   +5 more
openaire   +3 more sources

First insights into structure-function relationships of alkylglycerol monooxygenase

Pteridines, 2013
Alkylglycerol monooxygenase is a tetrahydrobiopterin-dependent enzyme that cleaves the O-alkyl-bond of alkylglycerols. It is an exceptionally unstable, hydrophobic membrane protein which has never been purified in active form.
Watschinger Katrin, Fuchs Julian E., Yarov-Yarovoy Vladimir, Keller Markus A., Golderer Georg, Hermetter Albin, Werner-Felmayer Gabriele, Hulo Nicolas, Werner Ernst R.   +8 more
doaj   +1 more source

Perspectives on tetrahydrobiopterin research.

Folia Pharmacologica Japonica, 2001
Tetrahydrobiopterin ((6R)-L-erythro-tetrahydrobiopterin, BH4) is de novo synthesized from GTP. Enzymes involved in its synthesis are the rate limiting enzyme GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase. Abnormalities in the metabolism of BH4 have been demonstrated in some diseases affecting the central ...
C, Sumi-Ichinose, M, Ohtsuki, H, Shiraishi, T, Nomura   +3 more
openaire   +3 more sources