Results 31 to 40 of about 26,569 (299)

7-Tetrahydrobiopterin is an uncoupled cofactor for rat hepatic phenylalanine hydroxylase [PDF]

, 1991
Rat hepatic phenylalanine hydroxylase requires both a tetrahydropterin cofactor and molecular oxygen to convert phenylalanine to tyrosine. During the physiological hydroxylation, a single mol of the natural cofactor, tetrahydrobiopterin, is oxidized for ...
Davis, Michael D., Kaufman, Seymour
core   +1 more source

The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders [PDF]

, 2016
INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases ...
Cortès Saladelafont, Elisenda, Fernández Ramos, Joaquín A., Friedman, Jennifer, Garcia Cazorla, Àngels, Honzik, Tomas, Horvath, Gabriella, Jeltsch, Kathrin, Jung Klawitter, Sabine, Kurian, Manju A., Kuseyri, Oya, Lopez Laso, Eduardo, MASTRANGELO, Mario, Opladen, Thomas, Pearson, Toni, Pons, Roser, Scholl Bürgi, Sabine, Wassenberg, Tessa   +16 more
core   +1 more source

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

Journal of Clinical Investigation, 2003
Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become "uncoupled," producing reactive oxygen species (ROSs) rather than NO.
U. Landmesser, S. Dikalov, S. Price, Louise A. McCann, T. Fukai, S. Holland, W. Mitch, D. Harrison   +7 more
semanticscholar   +1 more source

Tetrahydrobiopterin.

Current Hypertension Reports, 2020
The endothelium plays a pivotal role in vascular physiology through a variety of factors, foremost of which is nitric oxide (NO). However, the biochemical mechanisms leading to reduced NO availability and subsequent endothelial dysfunction are not ...
M. Ozkor, A. Quyyumi
semanticscholar   +1 more source

TETRAHYDROBIOPTERIN BIOSYNTHESIS [PDF]

, 1982
published
Curtius, Hans-Christoph, Häusermann, Max, Niederwieser, Alois, Ghisla, Sandro   +3 more
openaire   +2 more sources

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines, 2013
Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin.
Cardini Benno, Oberhuber Rupert, Hein Sven R., Watschinger Katrin, Hermann Martin, Obrist Peter, Werner-Felmayer Gabriele, Brandacher Gerald, Pratschke Johann, Werner Ernst R., Maglione Manuel   +10 more
doaj   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

PLoS ONE, 2014
ObjectiveAim of this study was to identify the nitric oxide synthase (NOS) isoform involved in early microcirculatory derangements following solid organ transplantation.BackgroundTetrahydrobiopterin donor treatment has been shown to specifically ...
Benno Cardini, Katrin Watschinger, Martin Hermann, Peter Obrist, Rupert Oberhuber, Gerald Brandacher, Surawee Chuaiphichai, Keith M Channon, Johann Pratschke, Manuel Maglione, Ernst R Werner   +10 more
doaj   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source