Results 101 to 110 of about 30,694 (295)

Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide

, 2020
(-)-Δ-9-tetrahydrocannabinol ((-)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (-)-11-hydroxy-Δ-9-tetrahydrocannabinol ((-)-11-OH-Δ-9-THC), which is psychoactive, and to (-)-11-nor-9-carboxy-Δ-
Clausen, Florian, Hassenberg, Christoph, Hoffmann, Grete, Schürenkamp, Jennifer, Studer, Armido   +4 more
core   +1 more source

Cis–Trans Rotational Isomerism of Formic Acid, Sulfur, and Selenium Analogues and Their Dimers: Chemical Kinetics Under Interstellar Conditions

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT We present chemical kinetic rate constants for the cis to trans isomerisation or rotamerization of monomeric seleno‐, thio‐, and formic acids and that of three of their dimeric species, based on variational transition state theory and multidimensional tunneling calculations in the gas‐phase, from 10 K to 300 K. These provide, firstly, reliable
Judith Wurmel, John M. Simmie
wiley   +1 more source

SYSTEMATIC REVIEW OF MEDICINAL BENEFITS OF CANNABIS SATIVA L. AND ITS IMPACT ON SOCIO-ECONOMIC DEVELOPMENT.

Student's Journal of Health Research Africa
Medical Cannabis sativa inflorescence has gained popularity in recent years due to the therapeutic pharmacological characteristics of its components. Cannabis sativa L.-based drugs are effective in treating a variety of illnesses, including constipation,
Sipho Goge, Karishma Singh, Kuben Naidoo   +2 more
doaj   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

A Brief but Concise History of the Discovery and Elucidation of the Structure of the Major Cannabinoids

Psychoactives
The history of cannabis research spans centuries, with a focus on isolating and understanding its active compounds. Although plants like opium and coca yielded active alkaloids relatively early, cannabis posed unique challenges due to its active ...
Lumír Ondřej Hanuš, Leonid N. Maslov
doaj   +1 more source

Optimal condition of cannabis maceration to obtain the high cannabidiol and Δ9-tetrahydrocannabinol content

, 2019
: The aim of this work was to optimize a maceration condition of cannabis (Cannabis sativa L.). A circumscribed central composite experimental design was applied in this work.
FAMEERA MADAKA (7503374), SUKANYA SETTHARAKSA (7503377), THANIYA WUNNAKUP (7503380), THANAPAT SONGSAK (7503386), CHAOWALIT MONTON (7503371), JIRAPORNCHAI SUKSAEREE (7503383)   +5 more
core   +1 more source

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

Recent Preclinical Evidence on Phytocannabinoids in Neurodegenerative Disorders: A Focus on Parkinson’s and Alzheimer’s Disease

Pharmaceuticals
The endocannabinoid system (ECS) is a vital biological network essential for maintaining homeostasis and supporting various physiological functions. It comprises cannabinoid receptors, endogenous lipid-based ligands, known as endocannabinoids, as well as
Nicoleta-Mirela Blebea, Ciprian Pușcașu, Gabriel Hancu, Alina Mihaela Stăniguț, Cornel Chiriță   +4 more
doaj   +1 more source

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco, Daniela Fortunato Rêgo, Carolina de Oliveira Cruz Latorraca, Marco Aurelio de Carvalho Nascimento, André Bastos Daher, Rachel Riera   +5 more
wiley   +1 more source

Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Analysis of Δ9-Tetrahydrocannabinol and Cannabidiol in Commercial Suk-Saiyasna Herbal Remedy: Applying Hansen Solubility Parameters for Sample Extraction to Ensure Regulatory Compliance

Pharmaceuticals
Background: Suk-Saiyasna is a traditional Thai herbal remedy that comprises 12 distinct herbs. Among these, cannabis leaves constitute 12 of the total 78 components in this formulation.
Suwimon Sumontri, Wanna Eiamart, Sarin Tadtong, Weerasak Samee   +3 more
doaj   +1 more source