Results 171 to 180 of about 30,694 (295)

(+)‐Trans‐Cannabidiol Is an Agonist at Human CB2 Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Pedro Bans Burtchaell, Marina Junqueira Santiago, Chenxi Wang, Mehdi Hagdoost, Evie J. M. Clay, Dani Mohnot, Mark Connor   +6 more
wiley   +1 more source

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

Addiction, Volume 121, Issue 10, Page 2822-2832, October 2026.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen, Irma S. van den Hengel‐Koot, Claudine C. Hunault, Dylan W. de Lange, Antoinette J. H. P. van Riel, Laura Hondebrink   +5 more
wiley   +1 more source

Cannabis consumer responses to the concept of standard THC units

Addiction, Volume 121, Issue 10, Page 2747-2756, October 2026.
Abstract Aims Within a context of considerable cannabis market expansion and product diversification, cannabis consumers must manage their use across a range of potencies and modes of consumption. This study aimed to provide deeper understandings of how cannabis consumers would perceive the introduction of a standard THC (tetrahydrocannabinol) unit ...
Mark Pawson, Mike Vuolo, Brian C. Kelly
wiley   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Selective Detection of Methamphetamine Hydrochloride Using Fluorescent Benzo[ghi]perylenetriimide Thin Films in a Single‐Channel Detector·

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This study reports fluorescent benzo[ghi]perylenetriimide films incorporated into a simple device architecture that can selectively detect methamphetamine hydrochloride (MA•HCl) over 3,4‐methylenedioxyamphetamine hydrochloride, cocaine hydrochloride, and fentanyl hydrochloride with a limit of detection of 10 ng.
Shengqiang Fan, Guanran Zhang, Oliver Lindsay, Paul L. Burn, Ian R. Gentle, Paul E. Shaw   +5 more
wiley   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, Volume 13, Issue 50, 7 September 2026.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Comparing the Impact of Tetrahydrocannabinol on 30‐Day Readmission Rates and Hospital Length of Stay in Patients With Depression

Brain and Behavior, Volume 16, Issue 9, September 2026.
Among patients hospitalized for major depressive disorder, a positive THC urine drug screen was not independently associated with 30‐day psychiatric readmission or hospital length of stay. These findings suggest that patient factors beyond THC exposure may have a greater influence on hospitalization outcomes.
Mohammed E. Khedr, Yunjin Lee, Muhammed A. Mirza, Humberto Jimenez, Daniel Greer   +4 more
wiley   +1 more source

Determination of THC and THC-COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study. [PDF]

Drug Test Anal
Bantle M, Schirmer W, Bruegger J, Wüthrich T, Längin A, Zwicker L, Auer R, Weinmann W.   +7 more
europepmc   +1 more source

Mechanism-Based Pharmacokinetic and Pharmacodynamic Modeling. [PDF]

Pharmaceutics
Świerczek A.
europepmc   +1 more source

Safety of synthetic cannabidiol as a novel food pursuant to regulation (EU) 2015/2283. [PDF]

EFSA J
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on cannabidiol (CBD) obtained by chemical synthesis as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Cámara M, Castenmiller J, De Henauw S, Jos Á, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Cubadda F, McArdle HJ, Trezza V, Albert O, Beneventi E, Laganaro M, Nuin Garciarena I, Rossi A, Cruz SB, Seminati F, Magani M, Hirsch-Ernst KI.   +26 more
europepmc   +2 more sources