Results 1 to 10 of about 13,656 (172)

A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase. [PDF]

Front Insect Sci, 2022
Honeybees are important managed pollinators that perform important ecological and economic functions. In recent decades, the obligate ectoparasite Varroa destructor severely affected survival of honeybees as it either feeds on hemolymph and fat bodies or acts as a vector for viruses.
Mating M, Sharbati S, Einspanier R.
europepmc   +4 more sources

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L). [PDF]

Biosci Rep, 2022
Abstract Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large human longitudinal cohorts, safe and precise detection methodologies are ...
Leow MK, Rengaraj A, Narasimhan K, Verma SK, Yaligar J, Thu GLT, Sun L, Goh HJ, Govindharajulu P, Sadananthan SA, Michael N, Meng W, Gallart-Palau X, Sun L, Karnani N, Sze NSK, Velan SS.   +16 more
europepmc   +4 more sources

Sorbitol Uptake and Oxygen Transfer Shape AOX1 Promoter Induction in Formate Dehydrogenase‐Deficient Komagataella phaffii [PDF]

Microbial Biotechnology
In Komagataella phaffii, the use of formate as an AOX1 promoter (PAOX1) inducer in combination with sorbitol, a non‐repressive carbon source, has emerged as a promising alternative to methanol‐based expression systems.
Cristina Bustos, Rocio Cozmar, Julio Berrios, Patrick Fickers   +3 more
doaj   +2 more sources

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling [PDF]

Nature Communications
Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the mechanisms by which acetylation mediates therapy resistance remain ...
Jung Seok Hwang, JiHoon Kang, Jaehyun Kim, Kiyoung Eun, Sophia West, Hannah E. Bacho, Vanessa Avalos, Sydney Shuff, Dong M. Shin, Nabil F. Saba, Kelly R. Magliocca, Cheng-Kui Qu, Haian Fu, Suresh S. Ramalingam, Andrey A. Ivanov, Taro Hitosugi, Sumin Kang   +16 more
doaj   +2 more sources

Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum. [PDF]

PLoS ONE
Anaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS).
Yanlin Cai, Andreas Marquardt, David Schleheck, Nicolai Müller   +3 more
doaj   +2 more sources

Methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and correlated with patient’s poor prognosis

Pteridines, 2021
To investigate methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, biological function, and correlation with head and neck squamous cell carcinoma (HNSCC) patient’s prognosis.
Sun Biqiang, He Zhijun, Liu Gan, Fu Xiao, Chen Zhiyong, Li Guoli   +5 more
doaj   +1 more source

Crystal Structure and Sequence Analysis of N⁵, N¹⁰-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase Enzyme from Porphyromonas gingivalis

Crystals, 2023
The methylenetetrahydrofolate dehydrogenase–cyclohydrolase (FolD) enzyme has a dual activity of N5,N10-methylenetetrahydrofolate dehydrogenase and cyclohydrolase.
Sehyeok Im, Hackwon Do, Jisub Hwang, Youn-Soo Shim, Jun Hyuck Lee   +4 more
doaj   +1 more source

Prevalence and determinants of folic acid uptake among women of childbearing age in the Ho municipality of the volta region of Ghana

International Journal of Food Properties, 2022
Folic acid is an essential vitamin that is found in certain green lush vegetables, such as kale, spinach, and cabbage. An estimated 300,000 children are born with NTDs globally each year resulting in the death of approximately 88,000.
Lucy Makafui Nutakor, Stephen Manortey
doaj   +1 more source

A Common Polymorphism in the MTHFD1 Gene Is a Modulator of Risk of Congenital Heart Disease

Journal of Cardiovascular Development and Disease, 2022
Several environmental and genetic factors may influence the risk of congenital heart defects (CHDs), which can have a substantial impact on pediatric morbidity and mortality. We investigated the association of polymorphisms in the genes of the folate and
Nataša Karas Kuželički, Alenka Šmid, Maša Vidmar Golja, Tina Kek, Borut Geršak, Uroš Mazič, Irena Mlinarič-Raščan, Ksenija Geršak   +7 more
doaj   +1 more source

Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. [PDF]

PLoS ONE, 2014
BACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism.
Barry R Palmer, Sandy Slow, Katrina L Ellis, Anna P Pilbrow, Lorraine Skelton, Chris M Frampton, Suetonia C Palmer, Richard W Troughton, Tim G Yandle, Rob N Doughty, Gillian A Whalley, Michael Lever, Peter M George, Stephen T Chambers, Chris Ellis, A Mark Richards, Vicky A Cameron   +16 more
doaj   +1 more source