Results 11 to 20 of about 13,831 (202)

Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate

Biochemical and Biophysical Research Communications, 2014
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and ...
Zigmund Luka, Svetlana Pakhomova, Lioudmila V. Loukachevitch, Marcia E. Newcomer, Conrad Wagner   +4 more
openalex   +4 more sources

The Role of Serine Hydroxymethyltransferase and Methylene‐Tetrahydrofolate Dehydrogenase in Genome Stability

The FASEB Journal, 2015
The conversion of tetrahydrofolate (THF) to 5,10‐methyleneTHF is catalyzed by the isozymes serine hydroxymethyltransferase 1 and 2 (SHMT1, SHMT2) and the trifunctional enzyme methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). 5,10‐methyleneTHF is a cofactor for the enzyme thymidylate synthase (TYMS) in the conversion of deoxyuridylate (dUMP) to ...
Aislyn C. DiRisio, Elena Kamynina, Patrick J. Stover   +2 more
openalex   +2 more sources

Impact of Copper on the Physiology and Transcriptome of Methylosinus Trichosporium OB3b Grown on Either Methane or Methanol. [PDF]

Environ Microbiol
Methylosinus trichosporium OB3b can grow on methanol in the absence but not presence of copper due: (1) overgeneration of reducing power from methanol oxidation; (2) formate accumulation leading to acidification of the growth medium and inactivation of formate dehydrogenase; and (3) lack of expression of potential oxidative stress defence genes ...
Peng P, Semrau JD.
europepmc   +2 more sources

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Swanson MA, Jiang H, Kolora LD, Molino R, Reisdorph R, Michel CR, Doenges KA, Leung KY, Lin X, Wong F, Lancaster S, Michael B, Snyder M, Hock DH, Stroud DA, Wood T, Binard R, Anderson-Lehman L, Christians U, Arning E, Friederich MW, Van Hove RA, MacLean KN, Greene NDE, Van Hove JLK.   +24 more
europepmc   +2 more sources

Anaerobic Carbon Monoxide Dehydrogenase Diversity in the Homoacetogenic Hindgut Microbial Communities of Lower Termites and the Wood Roach [PDF]

, 2011
Anaerobic carbon monoxide dehydrogenase (CODH) is a key enzyme in the Wood-Ljungdahl (acetyl-CoA) pathway for acetogenesis performed by homoacetogenic bacteria.
A Brauman, A Ebert, A Marchler-Bauer, B Soboh, BJ Paster, CL Drennan, CL Drennan, CM Perez, DA Odelson, DM Bodenmiller, E Matson, E Oelgeschläger, E Pezacka, E Pierce, EG Matson, EJ Gagen, Eric G. Matson, F Warnecke, FH Martin, GM King, H Dobbek, HJ Beaumont, HL Drake, HL Drake, HL Drake, HL Drake, J Heo, J Heo, JA Breznak, JA Breznak, Jared R. Leadbetter, JG Ferry, JM González, JR Graber, JR Graber, JR Leadbetter, K Fujinaga, Kasia G. Gora, KH Yeoman, M Köpke, M Pester, M Wu, MA Larkin, MD Kane, R Overbeek, RE Hungate, RL Kerby, S Huang, S Kambhampati, SF Altschul, SW Ragsdale, SW Ragsdale, SW Ragsdale, SW Singer, T Beckwith, TG Lilburn, TI Doukov, TM Salmassi, V Svetlitchnyi, V Svetlitchnyi, Vasu D. Appanna, W Ludwig, X Zhang   +62 more
core   +11 more sources

Crystal Structure and Sequence Analysis of N⁵, N¹⁰-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase Enzyme from Porphyromonas gingivalis

Crystals, 2023
The methylenetetrahydrofolate dehydrogenase–cyclohydrolase (FolD) enzyme has a dual activity of N5,N10-methylenetetrahydrofolate dehydrogenase and cyclohydrolase.
Sehyeok Im, Hackwon Do, Jisub Hwang, Youn-Soo Shim, Jun Hyuck Lee   +4 more
doaj   +1 more source

Prevalence and determinants of folic acid uptake among women of childbearing age in the Ho municipality of the volta region of Ghana

International Journal of Food Properties, 2022
Folic acid is an essential vitamin that is found in certain green lush vegetables, such as kale, spinach, and cabbage. An estimated 300,000 children are born with NTDs globally each year resulting in the death of approximately 88,000.
Lucy Makafui Nutakor, Stephen Manortey
doaj   +1 more source

Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5. [PDF]

FASEB Bioadv
Exogenous formate administration reduces myocardial ischemic injury in intact alcohol dehydrogenase 5 knockout (ADH5−/−) female mice, but not in intact or ovariectomized wild‐type female mice. One‐carbon metabolism may play an intermediate role. This graphic was generated using BioRender.
Garbus-Grant H, Ebenebe-Kasonde OV, Kabir R, Kohr MJ.   +3 more
europepmc   +2 more sources

Physical map location of the Escherichia coli gene encoding the bifunctional enzyme 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methenyl-tetrahydrofolate cyclohydrolase. [PDF]

Journal of Bacteriology, 1991
G P Dimri, G F Ames, Loubna Dari, Jesse C. Rabinowitz   +3 more
openalex   +4 more sources

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +5 more sources