Results 51 to 60 of about 13,831 (202)

Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]

, 2018
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon, Van Der Straeten, Dominique   +1 more
core   +3 more sources

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [PDF]

, 2015
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
Abu-Remaileh, Monther, Chan, Sze Ham, Chen, Walter W., Cho, Sung Won, Chung, Haeyoon, Davidson, Shawn M, Fiske, Brian Prescott, Koh, Min Jung, Lewis, Caroline, Liu, Chieh Ming Jamin, Luengo, Alba, Pacold, Michael Edward, Sabatini, David, Sullivan, Lucas Bryan, Swier, Lotteke J. Y. M., Vander Heiden, Matthew G., Zhou, Minerva H.   +16 more
core   +1 more source

Serine one-carbon catabolism with formate overflow [PDF]

, 2016
Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris, Blyth, Karen, Gottlieb, Eyal, Kamphorst, Jurre J., Labuschagne, Christiaan Fred, Mackay, Gillian M., Maddocks, Oliver, Meiser, Johannes, Tumanov, Sergey, Van Den Broek, Niels, Vazquez, Alexei, Vousden, Karen   +11 more
core   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

Frontiers in Microbiology, 2018
Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride electron pair from NAD(P)H, coenzyme F420H2, H2, or formate is split by flavoproteins into one-electron with a more negative reduction potential and one with a more ...
Wolfgang Buckel, Rudolf K. Thauer
doaj   +1 more source

Draft Genome of Pseudomonas sp. Strain 11/12A, Isolated from Lake Washington Sediment. [PDF]

, 2015
We announce here the genome sequencing of Pseudomonas sp. strain 11/12A from Lake Washington sediment. From the genome content, a versatile lifestyle is predicted but not one of bona fide methylotrophy.
Chistoserdova, Ludmila, McTaggart, Tami L, Shapiro, Nicole, Woyke, Tanja   +3 more
core   +1 more source

Photorespiration: metabolic pathways and their role in stress protection [PDF]

, 2000
Photorespiration results from the oxygenase reaction catalysed by ribulose-1,5-bisphosphate carboxylase/ oxygenase. In this reaction glycollate-2-phosphate is produced and subsequently metabolized in the photorespiratory pathway to form the Calvin ...
Anderson L. E., Astrid Wingler, C. B. Osmond, C. H. Foyer, Downton W. J. S., G. Bock, Kacser H., Koch K. E., Nakamura Y., Noctor G., Noctor G., Nour J. M., Nour J. M., Osmond C. B., Peter J. Lea, Richard C. Leegood, Richardson K. E., Ruban A.V., Tolbert N. E., W. Paul Quick, Walker R. R., Wingler A.   +21 more
core   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

The pugilistDominant Mutation of Drosophila melanogaster: A Simple-Sequence Repeat Disorder Reveals Localized Transport in the Eye.

PLoS ONE, 2016
The pugilist-Dominant mutation results from fusion of a portion of the gene encoding the tri-functional Methylene Tetrahydrofolate Dehydrogenase (E.C.1.5.1.5, E.C.3.5.4.9, E.C.6.3.4.3) to approximately one kb of a heterochromatic satellite repeat ...
Yikang S Rong, Mary M Golic, Kent G Golic   +2 more
doaj   +1 more source

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Human Genomics, 2020
Background Mitochondrial folate enzyme ALDH1L2 (aldehyde dehydrogenase 1 family member L2) converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 simultaneously producing NADPH.
Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Kristi L. Helke, Madeline S. Hall, Xiuxia Du, Susan Sumner, Sergey A. Krupenko   +7 more
doaj   +1 more source