Results 51 to 60 of about 13,656 (172)

High expression of folate metabolic pathway gene MTHFD2 is related to the poor prognosis of patients and may apply as a potential new target for therapy of NSCLC

Pteridines
Data mining was applied to explore the expression, functional enrichment, and signal pathway of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) gene in non-small cell lung cancer (NSCLC) and its relationship with patient prognosis.
Zhang Xin, Yang Peiying, Meng Guangxian
doaj   +1 more source

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. [PDF]

, 2015
Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism. GLDC mutations cause a rare recessive disease non-ketotic hyperglycinemia (NKH).
Brosnan, JT, Brosnan, ME, Copp, AJ, Greene, ND, Heales, S, Hutchin, T, Leung, KY, Pai, YJ, Prunty, H, Savery, D   +9 more
core   +1 more source

The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases [PDF]

Biochemical Journal, 1982
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at the end of the rapid phase of reduction of ETF is only ...
D J, Steenkamp, M, Husain
openaire   +2 more sources

Oncometabolites: tailoring our genes [PDF]

, 2015
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core   +1 more source

Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 [PDF]

, 2020
Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals.
Lea-Smith, David, McCormick, Alistair J., Mills, Lauren   +2 more
core   +3 more sources

Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate

Biochemical and Biophysical Research Communications, 2014
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and ...
Zigmund, Luka, Svetlana, Pakhomova, Lioudmila V, Loukachevitch, Marcia E, Newcomer, Conrad, Wagner   +4 more
openaire   +3 more sources

Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects. [PDF]

, 2014
BackgroundNeural tube defects (NTDs), which are among the most common congenital malformations, are influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor, making variants in genes in the folate ...
Abaan, Hatice Ozel, Brody, Lawrence C, Browne, Marilyn L, Caggana, Michele, Kay, Denise M, Kirke, Peadar N, McGrath, Emily C, Mills, James L, Molloy, Anne M, Pangilinan, Faith, Parle-McDermott, Anne, Scott, John M, Shane, Barry, Sutton, Marie, Troendle, James F   +14 more
core   +3 more sources

The Role of Serine Hydroxymethyltransferase and Methylene‐Tetrahydrofolate Dehydrogenase in Genome Stability

The FASEB Journal, 2015
The conversion of tetrahydrofolate (THF) to 5,10‐methyleneTHF is catalyzed by the isozymes serine hydroxymethyltransferase 1 and 2 (SHMT1, SHMT2) and the trifunctional enzyme methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). 5,10‐methyleneTHF is a cofactor for the enzyme thymidylate synthase (TYMS) in the conversion of deoxyuridylate (dUMP) to ...
Aislyn DiRisio, Elena Kamynina, Patrick Stover   +2 more
openaire   +1 more source

MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions

Redox Report
Objectives: Cancer cells undergo metabolic reprogramming to adapt to high oxidative stress, but little is known about how metabolic remodeling enables gastric cancer cells to survive stress associated with aberrant reactive oxygen species (ROS ...
Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian   +7 more
doaj   +1 more source

Identification of Proteins and Genes Expressed by Methylophaga thiooxydans During Growth on Dimethylsulfide and Their Presence in Other Members of the Genus

Frontiers in Microbiology, 2019
Dimethylsulfide is a volatile organic sulfur compound that provides the largest input of biogenic sulfur from the oceans to the atmosphere, and thence back to land, constituting an important link in the global sulfur cycle.
Eileen Kröber, Hendrik Schäfer
doaj   +1 more source