Results 11 to 20 of about 4,486 (199)
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines [PDF]
Molecules, 2015 A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome
Mohamed Mihoubi +8 more
doaj +3 more sources
Near-Infrared-Light-Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology. [PDF]
Angew Chem Int Ed EnglThis minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Pagire SK +3 more
europepmc +3 more sources
Transaminase and Norcoclaurine Synthase One-Pot Cascades Towards (1S)-Tetrahydroisoquinolines. [PDF]
ChembiochemA TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Zhao J +5 more
europepmc +2 more sources
Biocatalytic production of tetrahydroisoquinolines [PDF]
Tetrahedron Letters, 2012 The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Ruff, Bettina M. +2 more
openaire +4 more sources
Biological Activities of Tetrahydroisoquinolines Derivatives
Журнал органічної та фармацевтичної хімії, 2023 1,2,3,4-Tetrahydroisoquinoline (THIQ) is a common scaffold of many alkaloids isolated from several plants and mammalian species. THIQ derivatives possess a broad spectrum of biological activities, including antitumor, antitubercular, antitrypanosomal ...
Maryam A. Jordaan, Oluwakemi Ebenezer
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Iridium-Catalyzed Asymmetric Intramolecular Allylic Amidation:Enantioselective Synthesis of Chiral Tetrahydroisoquinolines and Saturated Nitrogen Heterocycles [PDF]
, 2011 For the first time iridium catalysis has been used for the synthesis of chiral tetrahydroisoquinolines with excellent yields and high enantioselectivities (see scheme; cod=1,5-cyclooctadiene, DBU=1,8-diazabicyclo[5.4.0]undec-7-ene).
Bartels +32 more
core +6 more sources
Green Synthesis and Catalysis, 2021 Isoindolinone- and tetrahydroisoquinoline-based cyclic scaffolds comprise the key, structural feature of a wide range of biologically active molecules.
Ze-Dong Mou, Xia Zhang, Dawen Niu
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Results in Chemistry, 2022 The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata +5 more
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Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To evaluate the antibacterial activity of ten synthetic tetrahydroisoquinolines against eight bacterial strains. Methods: The ten tetrahydroisoquinolines synthesized via base-catalyzed Pictet–Spengler cyclization were screened against a total ...
Moses Njutain Ngemenya +3 more
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IUCrData, 2017 In the title compound, C23H23ClN2O4S, the 4-chlorophenyl ring is inclined to the pyridine ring of the isoquinoline group by 71.86 (13)°. In the crystal, molecules are linked by pairs of O—H...O hydrogen bonds, forming inversion dimers, which stack along ...
Joel T. Mague +4 more
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