Results 11 to 20 of about 1,536 (171)

Electrocatalytic C(sp3)–H/C(sp)–H cross-coupling in continuous flow through TEMPO/copper relay catalysis

Beilstein Journal of Organic Chemistry, 2021
Electrocatalytic dehydrogenative C(sp3)–H/C(sp)–H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis.
Bin Guo, Hai-Chao Xu
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Extending the Scope of the New Variant of the Castagnoli–Cushman Cyclocondensation onto o-Methyl Benzoic Acids Bearing Various Electron-Withdrawing Groups in the α-Position

Molecules, 2022
Based on the previously reported involvement of homophthalic acid monoesters in the Castagnoli–Cushman reaction-type cyclocondensation with imines, we tested a number of other o-methyl benzoic acids bearing various electron-withdrawing groups in the α ...
Natalia Guranova, Lyudmila Yakovleva, Olga Bakulina, Dmitry Dar’in, Mikhail Krasavin   +4 more
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Biological Activities of Tetrahydroisoquinolines Derivatives

Журнал органічної та фармацевтичної хімії, 2023
1,2,3,4-Tetrahydroisoquinoline (THIQ) is a common scaffold of many alkaloids isolated from several plants and mammalian species. THIQ derivatives possess a broad spectrum of biological activities, including antitumor, antitubercular, antitrypanosomal ...
Maryam A. Jordaan, Oluwakemi Ebenezer
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Biocatalytic production of tetrahydroisoquinolines [PDF]

Tetrahedron Letters, 2012
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Ruff, Bettina M., Bräse, S., O'Connor, Sarah E.   +2 more
openaire   +4 more sources

Catalytic asymmetric umpolung reaction of imines to synthesize isoindolinones and tetrahydroisoquinolines

Green Synthesis and Catalysis, 2021
Isoindolinone- and tetrahydroisoquinoline-based cyclic scaffolds comprise the key, structural feature of a wide range of biologically active molecules.
Ze-Dong Mou, Xia Zhang, Dawen Niu
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Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
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In vitro screening of 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines: Structure related activity against pathogenic bacteria

Asian Pacific Journal of Tropical Biomedicine, 2015
Objective: To evaluate the antibacterial activity of ten synthetic tetrahydroisoquinolines against eight bacterial strains. Methods: The ten tetrahydroisoquinolines synthesized via base-catalyzed Pictet–Spengler cyclization were screened against a total ...
Moses Njutain Ngemenya, Joelle Ngo Hanna, Julios Armand Komtchou, Simon Mbua Ngale Efange   +3 more
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Methyl 2-{[(6S*,7R*,8S*)-7-acetyl-8-(4-chlorophenyl)-4-cyano-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetate

IUCrData, 2017
In the title compound, C23H23ClN2O4S, the 4-chlorophenyl ring is inclined to the pyridine ring of the isoquinoline group by 71.86 (13)°. In the crystal, molecules are linked by pairs of O—H...O hydrogen bonds, forming inversion dimers, which stack along ...
Joel T. Mague, Elham A. Al-Taifi, Shaaban K. Mohamed, Mehmet Akkurt, Etify A. Bakhite   +4 more
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Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines

Molecules, 2021
It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out ...
Sheng-Han Huang, Wan-Yu Huang, Guo-Lun Zhang, Te-Fang Yang   +3 more
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Promising activity of tetrahydroisoquinolines against multidrug-resistant clinical Salmonella isolates and cytotoxicity against monkey kidney cells

Scientific African, 2022
The high burden of Salmonella infections has been aggravated by the emergence and spread of multidrug-resistant strains affecting almost all antibiotic classes recommended for treatment.
Joelle Ngo Hanna, Rita A. Ndip, Moses N. Ngemenya, Casey R. Simons, Flavien A. A. Toze, Stephen M. Ghogomu, James A. Mbah   +6 more
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