Results 31 to 40 of about 1,536 (171)

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

DDQ-Promoted Mild and Efficient Metal-Free Oxidative α-Cyanation of N-Acyl/Sulfonyl 1,2,3,4-Tetrahydroisoquinolines

Molecules, 2018
A mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) has been accomplished at an ambient temperature via DDQ oxidation and subsequent trapping of N-acyl/sulfonyl iminium ions with (n-
Hong Pyo Kim, Heesun Yu, Hyoungsu Kim, Seok-Ho Kim, Dongjoo Lee   +4 more
doaj   +1 more source

Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts

Beilstein Journal of Organic Chemistry, 2020
A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs.
David Schönbauer, Carlo Sambiagio, Timothy Noël, Michael Schnürch   +3 more
doaj   +1 more source

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines

Molecules, 2022
A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported.
Kaikai Wang, Yanli Li, Wei Zhang, Rongxiang Chen, Xueji Ma, Mingyue Wang, Nan Zhou   +6 more
doaj   +1 more source

Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines

Molecules, 2018
A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations.
Csilla Hargitai, Tamás Nagy, Judit Halász, Gyula Simig, Balázs Volk   +4 more
doaj   +1 more source

Unified Synthesis of Unconventional α‐Polyhalogenated Amines Through Hydroaminoalkylation

Angewandte Chemie International Edition, EarlyView.
A unified, redox‐neutral method that transforms alkenes and alkynes into α‐polyhalomethyl amines using stable hemiaminal reagents is reported. This approach enables access to CF3, CF2H, CF2Cl, and CFClH motifs, expanding halogenated amine space with broad substrate scope, functional group tolerance, and applicability to late‐stage modification of drug ...
Angela K. Hofmeister, Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, Nuno Maulide   +9 more
wiley   +1 more source

New Strategy for the Synthesis of Tetrahydroisoquinoline Alkaloids [PDF]

Organic Letters, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Philip, Magnus, Kenneth S, Matthews, Vince, Lynch   +2 more
openaire   +2 more sources

Toward Rational Understandings of α-C–H Functionalization: Energetic Studies of Representative Tertiary Amines

iScience, 2020
Summary: Functionalization of α-C–H bonds of tertiary amines to build various α-C–X bonds has become a mainstream in synthetic chemistry nowadays. However, due to lack of fundamental knowledge on α-C–H bond strength as an energetic guideline, rational ...
Wenzhi Luo, Jin-Dong Yang, Jin-Pei Cheng
doaj   +1 more source

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

Beilstein Journal of Organic Chemistry, 2017
Background: 1,2,3,4-Tetrahydroisoquinolines (THIQs) are common motifs in alkaloids and in medicinal chemistry. Synthetic access to THIQs via the Pomeranz–Fritsch–Bobbit (PFB) methodology using mineral acids for deactivated, electron-poor aromatic systems,
Marco Mottinelli, Mathew P. Leese, Barry V. L. Potter   +2 more
doaj   +1 more source

Cross‐Dehydrogenative Coupling Reactions With Redox‐Active Guanidine Reagents

Chemistry – A European Journal, EarlyView.
ABSTRACT Cross‐dehydrogenative coupling (CDC) reactions are attractive and environmentally friendly ways to form new C‐C and other element‐element bonds. Here, we report the first CDC reactions triggered by a redox‐active guanidine reagent. N‐phenyltetrahydroisoquinoline and derivatives with electron‐donating and withdrawing substituents at the N ...
Petra Walter, Olaf Hübner, Hans‐Jörg Himmel   +2 more
wiley   +1 more source