Results 51 to 60 of about 1,536 (171)

The One‐Step Synthesis of Biologically Active Isochromans from Lignin‐Derived Aromatic Monomers in Tunable Deep Eutectic Solvents

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi, Anastasiia M. Afanasenko, Antonio A. Castillo‐Garcia, Walid A. M. Elgaher, Jörg Haupenthal, Anna K. H. Hirsch, Katalin Barta   +6 more
wiley   +1 more source

From Isocyanides to Iminonitriles via Silver-mediated Sequential Insertion of C(sp3)–H Bond

iScience, 2019
Summary: Heterocycles are prevalent constituents of many marketing drugs and biologically active molecules to meet modern medical challenges. Isocyanide insertion into C(sp3)–H bonds is challenging especially for the construction of quaternary carbon ...
Huiwen Chi, Hao Li, Bingxin Liu, Rongxuan Ye, Haoyang Wang, Yin-Long Guo, Qitao Tan, Bin Xu   +7 more
doaj   +1 more source

3D Liver Fibrosis Models in Lab: A Novel Modality for Drug Screening

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Liver fibrosis is the common consequence of liver injury caused by a variety of chronic liver disorders. This condition leads to the development of more severe complications, particularly cirrhosis and hepatocellular carcinoma. Despite abundant studies, the fundamental cell and molecular mechanisms of liver fibrosis are still unknown.
Hani Keshavarz Alikhani, Fatemeh Majidi, Mahsa Ghasemzad, Anastasia Shpichka, Anastasia Nestorova, Zahra Hendi, Elham Rismani, Daria Kuznetsova, Peter Timashev, Massoud Vosough, Abbas Piryaei   +10 more
wiley   +1 more source

Safracin B as a Synthetic Linchpin: From Natural Product to Drug Intermediate and Beyond

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Safracin B is employed as a key precursor for the streamlined preparation of cyanosafracin B and safracin A. Careful tuning of the reaction parameters affords these derivatives in high efficiency, and full nuclear magnetic resonance signal assignments are established for the complex safracin frameworks.
Paolo Orlando, Simone Borsoi, Valerio Fasano, Andrea Citarella, Pietro Allegrini, Daniele Passarella   +5 more
wiley   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

European Journal of Organic Chemistry, Volume 29, Issue 25, 4 July 2026.
A new series of structurally rich polyaromatic isonitriles is presented as photoredox catalysts. Their photophysical properties are investigated by UV–Vis absorption and fluorescence measurements, combined with experimental and theoretical studies to evaluate both ground‐ and excited‐state redox properties.
Cristina Martini, Camilla Russo, Jussara Amato, Carmine Volpe, Francesca Brunelli, Laurence Grimaud, Maxime R. Vitale, Greta Donati, Andrea Basso, Mariateresa Giustiniano   +9 more
wiley   +1 more source

Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution-Phase Chemistry

CHIMIA, 2003
Different techniques can be applied for the automated production of small and large compound collections. Large libraries that are often generated and tested during the lead-finding stage of a project are typically produced by solid-phase ...
Ralf Koberstein, Alexander Treiber, Thierry Sifferlen, Oliver Nayler, Celia Mueller, François Jenck, Walter Fischli, Martine Clozel, Daniel Bur, Hamed Aissaoui, Thomas Weller   +10 more
doaj   +1 more source

Synthesis of N-Flurbiprofen-Substituted 1,2,3,4-Tetrahydroisoquinolines

Proceedings
Isoquinoline alkaloids constitute a substantial category of natural products, among which 1,2,3,4-tetrahydroisoquinoline (THIQ) holds significance.
Diyana Dimitrova, Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov   +3 more
doaj   +1 more source

A Class of Promising Acaricidal Tetrahydroisoquinoline Derivatives: Synthesis, Biological Evaluation and Structure-Activity Relationships

Molecules, 2014
As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities
Rui Yang, Qiao Ruan, Bing-Yu Zhang, Zuo-Lue Zheng, Fang Miao, Le Zhou, Hui-Ling Geng   +6 more
doaj   +1 more source

Studies on tetrahydroisoquinolines. XX. A novel synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines.

Chemical and Pharmaceutical Bulletin, 1983
Treatment of a mixture of the p-quinol acetate (4) and aryl ethers with trifluoroacetic acid gave 8-aryl-1, 2, 3, 4-tetrahydroisoquinolines (1a-f) in good yields. Similar reaction of 4 and corypalline (3) afforded a corypalline dimer (5).
HARA, HIROSHI, HOSHINO, OSAMU, UMEZAWA, BUNSUKE   +2 more
openaire   +2 more sources