Results 71 to 80 of about 4,486 (199)

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Renaly I. de A. Rêgo, Hugo F. O. Pires, Arthur L. Dias, Maria Caroline R. B. Remigio, Humberto H. N. de Andrade, Pablo R. da Silva, Natália F. de Sousa, Luciana Scotti, Marcus T. Scotti, Mirian G. S. S. Salvadori, Ricardo D. de Castro   +10 more
wiley   +1 more source

From Isocyanides to Iminonitriles via Silver-mediated Sequential Insertion of C(sp3)–H Bond

iScience, 2019
Summary: Heterocycles are prevalent constituents of many marketing drugs and biologically active molecules to meet modern medical challenges. Isocyanide insertion into C(sp3)–H bonds is challenging especially for the construction of quaternary carbon ...
Huiwen Chi, Hao Li, Bingxin Liu, Rongxuan Ye, Haoyang Wang, Yin-Long Guo, Qitao Tan, Bin Xu   +7 more
doaj   +1 more source

Research Progress of Polyoxometalate‐Integrated Frameworks: Syntheses, Properties, and Applications

ChemistryEurope, Volume 4, Issue 4, April 2026.
This review systematically summarizes the integration of polyoxometalates with covalent organic frameworks, metal‐organic frameworks, hydrogen‐bonded organic frameworks, and emerging porous hosts. It highlights synergistic effects, synthesis strategies, and applications in catalysis, energy storage, sensing, and biomedicine, while addressing current ...
De‐Yin Wang, Zhang‐Di Liu, Rui Xing, Zi‐Hao Wei, Zaixiang Zhang, Yang Yang, Jin Zhu   +6 more
wiley   +1 more source

Studies on tetrahydroisoquinolines. XX. A novel synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines.

Chemical and Pharmaceutical Bulletin, 1983
Treatment of a mixture of the p-quinol acetate (4) and aryl ethers with trifluoroacetic acid gave 8-aryl-1, 2, 3, 4-tetrahydroisoquinolines (1a-f) in good yields. Similar reaction of 4 and corypalline (3) afforded a corypalline dimer (5).
HIROSHI HARA, OSAMU HOSHINO, BUNSUKE UMEZAWA   +2 more
openaire   +2 more sources

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution-Phase Chemistry

CHIMIA, 2003
Different techniques can be applied for the automated production of small and large compound collections. Large libraries that are often generated and tested during the lead-finding stage of a project are typically produced by solid-phase ...
Ralf Koberstein, Alexander Treiber, Thierry Sifferlen, Oliver Nayler, Celia Mueller, François Jenck, Walter Fischli, Martine Clozel, Daniel Bur, Hamed Aissaoui, Thomas Weller   +10 more
doaj   +1 more source

Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]

, 2016
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA, Croft, RA, Davis, OA, Doran, R, Morgan, KF   +4 more
core   +1 more source

Using MD Simulations to Understand the Impact of Directed Evolution on Oxygen Affinity in Amine Oxidases

ChemistryOpen, Volume 15, Issue 4, April 2026.
A combination of experimental and computational experiments has been used to understand oxygen needs for evolved amine oxidase enzymes. Two variants of amine oxidase from Aspergillus niger were shown to have different oxygen requirements in the oxidation of a model substrate, with molecular dynamics simulations used to model the differences between the
Christopher R. Field, Rowan Lindeque, Jonathan P. Dolan, Julie Østerby Madsen, Sam Hay, Nicholas J. Turner, John M. Woodley, Sebastian C. Cosgrove   +7 more
wiley   +1 more source

Native proteins in organic chemistry. Recent achievements in the use of non hydrolytic enzymes for the synthesis of pharmaceuticals [PDF]

, 2016
Financial support by the Spanish Ministerio de Economia y Competitividad (MINECO) through the CTQ-2013-44153-P project is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente, López Iglesias, María, Méndez Sánchez, Daniel   +2 more
core   +2 more sources