Results 61 to 70 of about 1,536 (171)

The improved synthesis of ROCKYPhos and its application for the asymmetric hydrogenation of dihydroisoquinoline derivatives

Журнал органічної та фармацевтичної хімії
An optimized approach to the multigram synthesis of [(1R,2R,3S)-(+)-1,2-dimethyl-2,3-bis(diphenylphosphinomethyl)cyclopentyl]methanol (ROCKYPhos, CatASium I®), a camphor-derived chiral diphosphine ligand, has been developed.
Vitalii A. Bilenko
doaj   +1 more source

Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines

Nature Communications, 2017
The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by ...
Benjamin R. Lichman, Jianxiong Zhao, Helen C. Hailes, John M. Ward   +3 more
doaj   +1 more source

Stereoselective oxidative C3–N bond dehydrogenation and aromatization of 1-carboxyl substituted tetrahydroisoquinolines employing pipecolate oxidase

Green Synthesis and Catalysis
The dehydrogenation of C–N bond in 1,2,3,4-tetrahydroisoquinolines (THIQs), especially 1-substituted THIQs, is a type of fascinating transformation owing to its utility in synthetic organic chemistry. Yet, the existing reports are limitedly known as C1–N
Shuyun Ju, Xiaoshu Zhou, Huanhuan Jin, Yang Yang, Lirong Yang, Jianping Wu   +5 more
doaj   +1 more source

Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?

Behavioral and Brain Functions, 2007
Background The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity. Converging evidence has implicated abnormalities of
Rothenberger Aribert, Hünnerkopf Regina, Riederer Franz, Walitza Susanne, Roessner Veit, Gerlach Manfred, Moser Andreas   +6 more
doaj   +1 more source

Employing Mechanochemistry in the Synthesis of N-Ibuprofen-Substituted 1,2,3,4-Tetrahydroisoquinolines

Proceedings
Mechanochemistry has emerged as a potential alternative for organic transformations, leveraging substrate availability, stability, and reduced solvent use.
Stanimir Manolov, Diyana Dimitrova, Iliyan Ivanov, Dimitar Bojilov   +3 more
doaj   +1 more source

Recent advances in visible light-induced C1(sp3)-H functionalization of tetrahydroisoquinolines for C–C bond formation

Green Chemistry Letters and Reviews
Tetrahydroisoquinolines (THIQs) are a significant class of nitrogen-containing heterocyclic compounds often occurring in natural products and pharmaceuticals, exhibiting excellent biological activities and chemical properties, and also having a wide ...
Kai Yang, Hanqing Wu, Xinlei Fu, Shen Shan, Ruoying Hu, Zhaowen Liu   +5 more
doaj   +1 more source

New tetrahydroisoquinolines bearing nitrophenyl group targeting HSP90 and RET enzymes: synthesis, characterization and biological evaluation

BMC Chemistry
In this study, new tetrahydroisoquinoline compounds were synthesized by reaction of 7-Acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8- (3-nitrophenyl or 4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thiones with methyl iodide, chloro acetonitrile, ethyl ...
Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Eman M. Sayed, Marwa Sharaky   +4 more
doaj   +1 more source

Electrochemical hydrogen isotope exchange of amines controlled by alternating current frequency. [PDF]

Faraday Discuss, 2023
Behera N, Gunasekera D, Mahajan JP, Frimpong J, Liu ZF, Luo L.   +5 more
europepmc   +1 more source

Formal nitrogen-to-carbon replacement in isoindolines to form indenes <i>via N</i>-alkyl tetrahydroisoquinolines. [PDF]

Chem Sci
Steele RT, Domack J, Sarpong R.
europepmc   +1 more source

Conformationally locked 7-aryl tetrahydroisoquinolines as dual acetylcholinesterase inhibitors and antioxidants: role of intramolecular hydrogen bonding and aryl electronics. [PDF]

Front Pharmacol
Ríos V, Linares-Pipón C, Maulén C, Castro-Álvarez A, Bradshaw B, Romero-Parra J, Cuellar MA, Martínez-Cifuentes M, Parra C.   +8 more
europepmc   +1 more source