Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]
, 2008 1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert +5 more
core +2 more sources
Optically active diaryl tetrahydroisoquinoline derivatives [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 2011 In (1R,3S)-6,7-dimethoxy-3-(methoxydiphenylmethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(31)H(31)NO(3), (I), and (1R,3S)-2-benzyl-3-[diphenyl(trimethylsiloxy)methyl]-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline, C(40)H(43)NO(3)Si, (II), the absolute configurations have been confirmed to be R and S at the isoquinoline 1- and 3-positions ...
Tricia, Naicker +3 more
openaire +2 more sources
Visible-light photoredox catalyzed synthesis of pyrroloisoquinolines via organocatalytic oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade with Rose Bengal [PDF]
, 2014 Pyrrolo[2,1-a]isoquinoline alkaloids have been prepared via a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization cascade using Rose Bengal as an organo-photocatalyst.
Lau, Jonathan +2 more
core +7 more sources
Synthesis of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid-Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer. [PDF]
ChemistryOpenSynthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Tivari S +7 more
europepmc +2 more sources
Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
Molecules, 2021 It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out ...
Sheng-Han Huang +3 more
doaj +1 more source
Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments [PDF]
, 2017 Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine of Parkinsonian patients on l-DOPA (l-dihydroxyphenylalanine) medication.
Bugajski, Andrzej +3 more
core +2 more sources
Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines
Molecules, 2011 A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides.
Iliyana Stefanova +4 more
doaj +1 more source
Scientific African, 2022 The high burden of Salmonella infections has been aggravated by the emergence and spread of multidrug-resistant strains affecting almost all antibiotic classes recommended for treatment.
Joelle Ngo Hanna +6 more
doaj +1 more source
Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench [PDF]
, 2016 Substituted N-tert-butoxycarbonyl (Boc)-1,2,3,4-tetrahydroisoquinolines were prepared and treated with n-butyllithium in THF at −50 °C to test the scope of the metallation and electrophilic quench.
Coldham, I. +3 more
core +1 more source
Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity
Angewandte Chemie, EarlyView.Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser +3 more
wiley +2 more sources