Results 191 to 200 of about 4,966 (204)

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Journal of Molecular Neuroscience, 2015
Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a molecule with multiple properties.
Chen, Hai-Yun, Xu, Da-Ping, Tan, Guo-Lian, Cai, Wei, Zhang, Gao-Xiao, Cui, Wei, Wang, Jin-Zhao, Long, Cheng, Sun, Ye-Wei, Yu, Pei, Tsim, Karl Wahkeung, Zhang, Zai-Jun, Han, Yi-Fan, Wang, Yu-Qiang   +13 more
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Antithrombotic Effects of Tetramethylpyrazine in In Vivo Experiments

International Journal of Hematology, 2001
In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1.5-fold compared with normal saline ...
J R, Sheu, G, Hsiao, Y M, Lee, M H, Yen
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[Protective mechanism of tetramethylpyrazine on cardiovascular system].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2023
Tetramethylpyrazine is the main component of Ligusticum chuanxiong. Studies have found that tetramethylpyrazine has a good protective effect against cardiovascular diseases. In the heart, tetramethylpyrazine can reduce myocardial ischemia/reperfusion injury by inhibiting oxidative stress, regulating autophagy, and inhibiting cardiomyocyte apoptosis ...
Chun-Kun, Yang, Qing-Quan, Pan, Kui, Ji, Chuan-Chao, Luo, Zhuang, Tian, Hong-Yuan, Zhou, Jun, Li   +6 more
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Blockade of Adrenergic and Cholinergic Transmissions by Tetramethylpyrazine

Planta Medica, 1981
The pharmacological actions of an amide alkaloid, tetramethylpyrazine (TMPZ), isolated from the stem of JATROPHA PODAGRICA H OOK (Euphorbiaceae) have been investigated on the electrically-evoked contractions, relaxations and twitches of some cholinergically- and adrenergically-innervated muscle preparations IN VITRO and IN VIVO.
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Pharmacokinetics of a New Tetramethylpyrazine Analogue CXC195 in Rats

Drug Research, 2013
To investigate the pharmacokinetical characteristics of a new neuroprotective drug CXC195 after intraperitoneal injection in rats.A single 10 mg · kg-1 of CXC195 was intraperitoneally injected to 8 rats after fasting overnight, respectively. 500 microliters of blood samples were collected at scheduled time before and after administration.
C, Wei, L, Kong, X, Wei, L, Chen, X, Liu, X, Zhang, X, Liu, H, Liu   +7 more
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Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats

Neurochemistry International, 2006
In traditional Chinese medicine, Ligusticum wallichii Franchat (Chuan Xiong) and its active ingredient tetramethylpyrazine (TMP) have been used to treat cardiovascular diseases and to relieve various neurological symptoms such as ischemic deficits. However, scientific evidence related to their effectiveness or precise modes of neuroprotective action is
Tsung-Kuei, Kao, Yen-Chuan, Ou, Jong-Song, Kuo, Wen-Yin, Chen, Su-Lan, Liao, Ching-Wen, Wu, Chun-Jung, Chen, Nai-Nu, Ling, Yong-Hong, Zhang, Wen-Huang, Peng   +9 more
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Tetramethylpyrazine in Vinegar: A Bibliometric Analysis and Synthetic Mechanism

Journal of Food Science
ABSTRACT Vinegar is widely recognized for its distinctive flavor, nutritional value, and numerous health benefits, which are particularly attributed to the presence of tetramethylpyrazine (TMP). TMP not only contributes to the aroma of vinegar but also exhibits significant anti‐inflammatory, antioxidant, and cardioprotective effects ...
Linfeng Xie, Yiwen Xiao, Ya Wang, Jiantao Liu, Boliang Gao, Bin Liu, Du Zhu   +6 more
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Tetramethylpyrazine-derived polyurethane for improved hemocompatibility and rapid endothelialization

Journal of Materials Chemistry B
Tetramethylpyrazine (TMP)-derived polyurethane with improving hemocompatibility and accelerating endothelialization functions shows great potential in promoting long-term patency of small-diameter vascular graft.
Baoliu Qu, Zhenzhen Hu, Weilong Tan, Bingyan Li, Yue Xin, Jinpeng Mo, Meilin Huang, Qinghua Wu, Yangling Li, Yingzhu Wu   +9 more
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The Crystal Structure of Tetramethylpyrazine

Journal of the American Chemical Society, 1951
Don T. Cromer, Aaron J. Ihde, H. L. Ritter   +2 more
openaire   +1 more source

Effects of tetramethylpyrazine on platelet aggregation.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 1988
Y A, Ding, M H, Yen
openaire   +1 more source