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Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
Chemical Communications, 2013Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest.
Herth, Matthias Manfred +5 more
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1,2,4,5-Tetrazines and Azolo[1,2,4,5]tetrazines: Synthesis and Reactions with Nucleophiles
Chemistry of Heterocyclic Compounds, 2013The literature data are summarized for synthetic methods and nucleophilic transformations of 1,2,4,5-tetrazines and azolo[1,2,4,5]tetrazines published predominantly from 1995 until 2012.
S. G. Tolshchina +2 more
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BODIPY‐Tetrazine Multichromophoric Derivatives
European Journal of Organic Chemistry, 2010AbstractNew dyes based on BODIPY and tetrazine fluorophores connected through a phenyl spacer have been synthesized and their absorption, emission and electrochemical properties characterized. BODIPY can be reversibly oxidized into a stable cation radical whereas tetrazine can be reduced to a stable anion radical.
Cécile Dumas‐Verdes +7 more
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Streamlining Tetrazine Synthesis
Chemical & Engineering News Archive, 2012Facile synthesis of promising tetrazine biochemical probes could be a big step forward for researchers who examine biochemistry as it happens in cells and live animals (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201201117). The advance, utilizing Lewis acid catalysts, might allow more researchers to make the probes in one pot from commercially available ...
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2015
[290-96-0] C2H2N4 (MW 82.07) InChI = 1S/C2H2N4/c1-3-5-2-6-4-1/h1-2H InChIKey = HTJMXYRLEDBSLT-UHFFFAOYSA-N ([4+2] cycloaddition, azadiene, and pyridazine) Alternative Names: s-tetrazine, sym-tetrazine. Physical Data: mp 99 °C.2 Solubility: sol most organic solvents. Form Supplied in: bright red crystals.
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[290-96-0] C2H2N4 (MW 82.07) InChI = 1S/C2H2N4/c1-3-5-2-6-4-1/h1-2H InChIKey = HTJMXYRLEDBSLT-UHFFFAOYSA-N ([4+2] cycloaddition, azadiene, and pyridazine) Alternative Names: s-tetrazine, sym-tetrazine. Physical Data: mp 99 °C.2 Solubility: sol most organic solvents. Form Supplied in: bright red crystals.
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Two heterocyclic 1,2,4,5-tetrazines
Acta Crystallographica Section C Crystal Structure Communications, 1994The title compounds, 6-bromo-1,4-dihydro-1,4-di(otolyl)-1,2,4,5-tetrazin-3(2H)-one, C 16 H 15 BrN 4 O, and 3,6-dibromo-1,4-dihydro-1,4-bis(p-methoxyphenyl)1,2,4,5-tetrazine, C 16 H 14 Br 2 N 4 O 2 , were prepared from 4-bromo-3-(o-tolyl)sydnone and 4-bromo-3-(pmethoxyphenyl)sydnone, respectively, in thf under ultrasonic irradiation, and identified with
M. Y. Yeh +3 more
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Unusual Investigation of Polycyclic Saturated Tetrazine: A Breakthrough to 1,2,4,5‐Tetrazine
Journal of Heterocyclic Chemistry, 2015The theoretical investigation of polycyclic saturated tetrazine is a novel process, and the reaction of 1,2,4,5‐tetrazine with diazomethane that undergoes polymerization reaction has been studied by using a computational method, and it gives dinitrogen (N2) as the major product. The spectroscopic studies, bond length, bond angle, heat of formation, and
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