Results 91 to 100 of about 25,716 (303)

Alkaline-earth (Be, Mg and Ca) bonds at the origin of huge acidity enhancements [PDF]

, 2018
The interaction between alkaline-earth derivatives with the general formula X2M (X = H, F and Cl; M = Be, Mg and Ca) and a set of Lewis bases, including first and second-row hydrides, namely YHn(Y = O, N, F, S, P and Cl) hydrides, as well as other ...
Alkorta, Ibon, Elguero, José, Montero-Campillo, M. Merced, Mó, Otilia, Sanz, Pablo, Yáñez, Manuel   +5 more
core   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine [PDF]

, 2013
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated.
Appala Raju, Popat Baban Mohite, Ramdas Bhanudas Pandhare, Shantaram Gajanan Khanage   +3 more
core   +1 more source

Dehydroabietylamine derived bistetrazoles from ultrasound-assisted pseudo-seven-component Ugi reactions act as efficient and selective inhibitors of cholinesterases

European Journal of Medicinal Chemistry Reports
The reaction of dehydroabiethylamine (DHA) with isocyanides and formaldehyde produces varying products depending on the conditions employed. In a 4-component Ugi reaction using benzyl isocyanide, paraformaldehyde, and TMS-azide, the anticipated tetrazole
Niels V. Heise, Antonia Schmidt, Jördis-Ann Schüler, René Csuk   +3 more
doaj   +1 more source

Concise Synthesis of Tetrazole Macrocycle [PDF]

Organic Letters, 2017
A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo
Abdelraheem, Eman M. M.; de Haan, Michel P.; Patil, Pravin; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Shaabani, Shabnam; Domling, Alexander   +7 more
openaire   +4 more sources

4-[(2H-Tetrazol-2-yl)methyl]benzonitrile

Acta Crystallographica Section E, 2008
The title compound, C9H7N5, was synthesized by reaction of 4-(bromomethyl)benzonitrile and 2H-tetrazole in the presence of KOH. The relative orientation of the planar tetrazole ring and the methylbenzonitrile moiety is (−)-anticlinal.
Zhi-Rong Qu, Zheng Xing
doaj   +1 more source

Mesoionische N‐Heterocyclische Olefine, Imine, Thione, Phosphinidene und ihre Anwendung in der Katalyse

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Dieser Mini‐Review behandelt die neuesten Fortschritte bei der Synthese, Reaktivität und metallfreien katalytischen Verwendung von mesoionischen N‐heterocyclischen Olefinen (mNHOs), Iminen (mNHIs), Thionen (mNHTs) und Phosphinidenen (mNHPs). Kurzzusammenfassung Übergangsmetallverbindungen sind allgemein für ihre Fähigkeit bekannt, kleine Moleküle zu ...
Subir Maji, Sreejyothi P., Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Synthesis of N-Fmoc-ProtectedAmino Alkyl Thiocyanates/Selenocyanates and their Applicationin the Preparation of 5-Substituted S/Se-Linked Tetrazoles [PDF]

, 2011
A novel class of N-Fmoc-protected amino alkyl thiocy- anates/selenocyanates has been prepared by thiocyanation/seleno-cyanation of the corresponding alkyl iodides. These thiocyanates/selenocyanates undergo a facile [2+3]-cycloaddition reaction
Basavalingappa, P. Vasantha, Hosahalli, P. Hemantha, Vommina, V. Sureshbabu   +2 more
core   +1 more source

Mesoionic N‐Heterocyclic Olefins, Imines, Thiones, Phosphinidenes and Their Application in Catalysis

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
This minireview covers recent advances in the synthesis, reactivity, and metal‐free catalytic uses of mesoionic N‐heterocyclic olefins (mNHOs), imines (mNHIs), thiones (mNHTs), and phosphinidenes (mNHPs). Abstract Transition metal compounds are widely known for their ability to activate small molecules and are excellent catalysts for a wide range of ...
Subir Maji, Sreejyothi P, Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Nitrile ylides: allenic and propargylic structures from pyrazinylnitrenes. Experimental and theoretical characterization [PDF]

, 2014
Matrix photolysis of 2-pyrazinyl azides/tetrazolo[1,5-a]pyrazines generates nitrile ylides 15 via pyrazinylnitrenes 13 and triazacycloheptatetraenes 14.
Addicott, Chris, Baraille, Isabelle, Bednarek, Pawel, Begue, Didier, Burgard, Riko, Guille, Emilie, Wentrup, Curt   +6 more
core   +2 more sources