Results 91 to 100 of about 19,065 (226)
British Journal of Haematology, Volume 208, Issue 4, Page 1437-1442, April 2026.We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García +5 more
wiley +1 more source
4-[(2H-Tetrazol-2-yl)methyl]benzonitrile
Acta Crystallographica Section E, 2008 The title compound, C9H7N5, was synthesized by reaction of 4-(bromomethyl)benzonitrile and 2H-tetrazole in the presence of KOH. The relative orientation of the planar tetrazole ring and the methylbenzonitrile moiety is (−)-anticlinal.
Zhi-Rong Qu, Zheng Xing
doaj +1 more source
Kinetic and Mechanistic Investigation of Asymmetric Organocatalytic Reactions
, 2008 The utilisation of the reaction progress kinetic methodology to advance the mechanistic understanding of the asymmetric proline catalysed aldol and α-aminoxylation reactions is demonstrated in this work.
Zotova, Natalia, Zotova, Natalia
core +1 more source
Alkaline-earth (Be, Mg and Ca) bonds at the origin of huge acidity enhancements [PDF]
, 2018 The interaction between alkaline-earth derivatives with the general formula X2M (X = H, F and Cl; M = Be, Mg and Ca) and a set of Lewis bases, including first and second-row hydrides, namely YHn(Y = O, N, F, S, P and Cl) hydrides, as well as other ...
Alkorta, Ibon +5 more
core +1 more source
Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer
Cancer Science, Volume 117, Issue 4, Page 1136-1147, April 2026.The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka +26 more
wiley +1 more source
Cross Linking and Degradation Mechanisms in Model Sealant Candidates [PDF]
Model compounds were investigated as to which type of heterocyclic ring is the most advantageous for curing sealants based on perfluoroalkylether chains. The relative thermal, thermal oxidative, hydrolytic, and fuel stability of potential crosslinks were
Ito, T. I. +4 more
core +1 more source
Low temperature matrix-isolation and solid state vibrational spectra of tetrazole [PDF]
, 2001 Infrared spectra of tetrazole (CN isolated in an argon matrix (T \10 K) and in the solid state (at room 4H2) temperature) were investigated. In the crystalline phase, tetrazole exists in its 1H-tautomeric form and new assignments of the vibrational ...
Bugalho, Susana C. S. +3 more
core +2 more sources
Electro‐Mediated Redox Functionalization of Conjugated 1,3‐Dienes
Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.This review aims at providing a comprehensive view of the emerging field of electro‐mediated functionalization of conjugated 1,3‐dienes, highlighting key developments, mechanistic insights, and remaining challenges. It highlights the efficient use of electron as the sole reagent to access highly substituted allylic compounds from simple and readily ...
Ophélie Montiège +3 more
wiley +1 more source
2-(1H-Tetrazol-5-yl)benzonitrile
Acta Crystallographica Section E, 2008 The title compound, C8H5N5, was synthesized from phthalonitrile. The benzonitrile and tetrazole rings are inclined at a dihedral angle of 37.14 (11)°.
Yu-Yuan Zhao +3 more
doaj +1 more source
Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking [PDF]
, 2018 Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the ...
Chen, Xingjuan +10 more
core +1 more source