Results 61 to 70 of about 19,065 (226)

Towards Universal Stimuli-Responsive Drug Delivery Systems: Pillar[5]arenes Synthesis and Self-Assembly into Nanocontainers with Tetrazole Polymers

Nanomaterials, 2021
In this work, we have proposed a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures—pillar[5]arenes and tetrazole-containing polymers.
Dmitriy N. Shurpik, Lyaysan I. Makhmutova, Konstantin S. Usachev, Daut R. Islamov, Olga A. Mostovaya, Anastasia A. Nazarova, Valeriy N. Kizhnyaev, Ivan I. Stoikov   +7 more
doaj   +1 more source

Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures [PDF]

, 2003
This paper compares several published methods for clustering chemical structures, using both graph- and fingerprint-based similarity measures. The clusterings from each method were compared to determine the degree of cluster overlap. Each method was also
Blankley, C.J., Raymond, J.W., Willett, P.   +2 more
core   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives

Orbital: The Electronic Journal of Chemistry, 2011
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activities of various novel 1,3,4-oxadiazole containing 5-phenyltetrazole.
Popat B. Mohite, V. H. Bhaskar
doaj   +1 more source

Multicomponent Reaction Based Synthesis of 1-Tetrazolylimidazo[1,5- a]pyridines [PDF]

, 2018
A series of unprecedented tetrazole-linked imidazo[1,5- a]pyridines are synthesized from simple and readily available building blocks. The reaction sequence involves an azido-Ugi-deprotection reaction followed by an acetic anhydride-mediated N-acylation ...
Diekstra, Elmar, Dömling, Alexander, Kalinowska-Tłuścik, Justyna, Kurhade, Santosh, Kurpiewska, Katarzyna, Sutanto, Fandi   +5 more
core   +3 more sources

AhBWR15, A Novel RLK Gene, Confers Resistance to Ralstonia solanacearum in Peanut

Plant Biotechnology Journal, EarlyView.
ABSTRACT Bacterial wilt (BW), a severe soil‐borne disease caused by Ralstonia solanacearum, significantly impedes global peanut production. Despite its impact, the mechanisms underlying BW resistance in peanut remain unclear. Herein, we selected the highly resistant variety Nongdahua108 (H108) and the susceptible variety Nongdahua107 (H107) to develop ...
Zenghui Cao, Kai Zhao, Hao Li, Xingli Ma, Di Cao, Yanzhe Li, Sasa Hu, Qian Ma, Yaoyao Li, Yi Fan, Mengtian Hou, Kunkun Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Rui Ren, Dongmei Yin   +16 more
wiley   +1 more source

Scope of tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the synthesis of triazoloquinoxalines, imidazoloquinoxalines, and rhenium complexes thereof

Beilstein Journal of Organic Chemistry, 2022
The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated.
Laura Holzhauer, Chloé Liagre, Olaf Fuhr, Nicole Jung, Stefan Bräse   +4 more
doaj   +1 more source

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine [PDF]

, 2013
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated.
Appala Raju, Popat Baban Mohite, Ramdas Bhanudas Pandhare, Shantaram Gajanan Khanage   +3 more
core   +1 more source

Tetrazoles via Multicomponent Reactions [PDF]

Chemical Reviews, 2019
Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial physicochemical properties.
Constantinos G. Neochoritis, Ting Zhao, Alexander Dömling   +2 more
openaire   +3 more sources

Substrate selectivity of human histidine methyltransferase METTL9

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Sadaf Ahmad, Laust Moesgaard, Christian W. Tornøe, Paulina Emmel, Klaudia Slusarczyk, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović   +7 more
wiley   +1 more source