Results 41 to 50 of about 45,106 (206)
Effect of Tetrodotoxin Pellets in a Rat Model of Postherpetic Neuralgia
Marine Drugs, 2018 Postherpetic neuralgia (PHN) is nerve pain caused by a reactivation of the varicella zoster virus. Medications are used to reduce PHN but their use is limited by serious side effects.
Bihong Hong +8 more
doaj +1 more source
Towards the timely detection of toxicants
, 2003 We address the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, recently invented for the specific purpose of studying non-stationary time series.
Grigolini, P., Gross, G., Ignaccolo, M.
core +2 more sources
Outbreak of a neurotoxic side-gilled sea slug (Pleurobranchaea sp.) in Argentinian coasts [PDF]
, 2015 Since 2009 we have been registering the outbreak of an unknown side-gilled sea slug of the genus Pleurobranchaea in coastal waters of Argentina, southwestern Atlantic Ocean.
Farias, Nahuel Emiliano +2 more
core +1 more source
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source
Marine Drugs, 2010 Sensory neurons in the dorsal root ganglion express two kinds of tetrodotoxin resistant (TTX-R) isoforms of voltage-gated sodium channels, NaV1.8 and NaV1.9. These isoforms play key roles in the pathophysiology of chronic pain.
Nobukuni Ogata +3 more
doaj +1 more source
Bigenomic transcriptional regulation of all thirteen cytochrome c oxidase subunit genes by specificity protein 1 [PDF]
Open Biology, 2013 Cytochrome c oxidase (COX) is one of only four known bigenomic proteins, with three mitochondria-encoded subunits and 10 nucleus-encoded ones derived from nine different chromosomes. The mechanism of regulating this multi-subunit, bigenomic enzyme is not
Shilpa S. Dhar +2 more
doaj +1 more source
Toxins, 2021 The invasion of the tetrodotoxin (TTX)-bearing silver-cheeked toadfish and potential poisoning due to its consumption (tetrodotoxication) threatens public safety in the Mediterranean Sea.
Georgios Christidis +5 more
doaj +1 more source
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
core +1 more source
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Total syntheses of Tetrodotoxin and 9-epiTetrodotoxin
Nature CommunicationsTetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTetrodotoxin from the abundant chemical ...
Peihao Chen +9 more
doaj +1 more source