Results 101 to 110 of about 25,457 (196)

Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4agonist – tegaserod [PDF]

, 2006
Background Excess cholesterol in bile and in blood is a major risk factor for the respective development of gallbladder disease and atherosclerosis. This lipid in excess negatively impacts the functioning of other smooth muscles, including the intestine.
Ronald Mathison, Eldon Shaffer, R Zapata, P Portincasa, F Azzaroli, SJ Lewis, WG Hardison, SN Marcus, DE Brenneman, TM Fridhandler, QW Xu, QW Xu, QW Xu, AJ Kaumann, A Nguyen, GF Longstreth, RS Fisher, MD Gershon, I Yamamoto, M Katschinski, P Schoenfeld, K Ono, J Behar, A Mansour, QW Xu, MF Stolk, ML Booker, JP Raufman, MC Lewis, K Burger, L Puglielli, AK Robertson, KY Stokes, P Portincasa, B Nagorna-Stasiak, Z Szilvassy, JR Herman, JG De Man, JJ Galligan, JJ Galligan, HH Iversen, H Kilbinger, M Kurjak, MR Briejer, NH Prins, S Graf, JR Grider, AE Foxx-Orenstein, JR Grider, MD Linnik, A Schikowski, GJ Sanger   +51 more
core   +1 more source

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]

Toxins (Basel), 2022
Hassoun AER, Ujević I, Jemaa S, Roje-Busatto R, Mahfouz C, Fakhri M, Nazlić N.   +6 more
europepmc   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
Sarah C. Finch, Michael J. Boundy, D. Tim Harwood   +2 more
doaj   +1 more source

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source

Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro*

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Ece Selçuk, David S. Silcock, Amanda Foust, Vicky Bousgouni, Mar Arias‐Garcia, Chris Bakal, Mustafa B. A. Djamgoz, Pinar Uysal‐Onganer   +7 more
wiley   +1 more source

Tetrodotoxine (TTX) in mosselen: Accumulatie experiment verswaterleiding Kijkuit, Yerseke

, 2016
In verband met de overschrijding van de concentratie tetrodotoxine (TTX) in het schelpdiervlees van oesters en mosselen in de Kom van de Oosterschelde (inclusief de verwaterpercelen) is dit gebied eind juni 2016, evenals de noordelijke tak van de Oosterschelde, gesloten voor schelpdierproductie en als verwatergebied.
Wijsman, J.W.M., Poelman, M.
openaire   +1 more source

Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding [PDF]

, 2018
In this work molecular modeling was applied to generate homology models of the pore region of the Na v 1.2 and Na v 1.8 isoforms of human voltage-gated sodium channels.
Blaney, Frank, Clare, Jeff, Dale, Tim, Guex, Nicolas, McLay, Iain, Robertson, Graeme, Scheib, Holger, Tate, Simon   +7 more
core