Results 111 to 120 of about 48,663 (220)

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes [PDF]

, 1986
Several cDNA clones coding for the high molecular weight (alpha) subunit of the voltage-sensitive Na channel have been selected by immunoscreening a rat brain cDNA library constructed in the expression vector lambda gt11.
Auld, Vanessa, Catterall, William A., Davidson, Norman, Downey, William, Dowsett, Andrew, Dunn, Robert, Fritz, Larry C., Goldin, Alan L., Lester, Henry A., Lübbert, Hermann, Marshall, John, Snutch, Terry P.   +11 more
core  

A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block [PDF]

, 2007
Voltage-gated sodium channels control the upstroke of the action potential in excitable cells of nerve and muscle tissue, making them ideal targets for exogenous toxins that aim to squelch electrical excitability.
Ahern, Christopher A., Dougherty, Dennis A., Eastwood, Amy L., Horn, Richard, Santarelli, Vincent P.   +4 more
core   +2 more sources

A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction [PDF]

, 1978
A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired.
Benzer, Seymour, Ganetzky, Barry, Jan, Lily Yeh, Jan, Yuh-Nung, Wu, Chun-Fang   +4 more
core  

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding [PDF]

, 2018
In this work molecular modeling was applied to generate homology models of the pore region of the Na v 1.2 and Na v 1.8 isoforms of human voltage-gated sodium channels.
Blaney, Frank, Clare, Jeff, Dale, Tim, Guex, Nicolas, McLay, Iain, Robertson, Graeme, Scheib, Holger, Tate, Simon   +7 more
core  

Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons

Experimental Physiology
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier   +4 more
doaj   +1 more source

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
Sarah C. Finch, Michael J. Boundy, D. Tim Harwood   +2 more
doaj   +1 more source

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

Marine Drugs
Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms.
Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu, Shuilin Cai, Qilin Huang, Zhiyu Liu   +6 more
doaj   +1 more source

A Deadly Poison Becomes a Useful Tool [PDF]

, 1966
The very high potency of TTX and its highly selective block of nerve and skeletal muscle fibers has already shed a great deal of light on their excitation properties and should lead to the ability to specify an entirely new type of anesthetic agent even ...
Moore, John W.
core   +1 more source

Proctolin and an Endogenous Proctolin-Like Peptide Enhance the Contractility of the Limulus Heart [PDF]

, 1983
Synthetic proctolin increases the force but not the rate of heart contractions of Limulus in a time- and dose-dependent manner. The threshold of this effect is 3 × 10−10M and the ED50 is approximately 10−8M. At concentrations up to 10−7 M, proctolin has
Augustine, George J., Sullivan, Robert E., Watson, Winsor H., III   +2 more
core   +2 more sources