Toxins, 2019 A novel polyclonal antibody against tetrodotoxin (TTX) was raised using its haptenic antigen, where 4,9-anhydroTTX was reacted with 1,2-ethanedithiol and this derivative was further reacted with keyhole limpet hemocyanin (KLH).
Shigeru Sato +3 more
doaj +1 more source
Rapid onset of neuronal death induced by blockade of either axoplasmic transport or action potentials in afferent fibers during brain development. [PDF]
, 1992 We have investigated how neurons in the optic tecta of embryonic day 16 chick embryos depend for survival on their afferents from the retina. To distinguish between activity-mediated effects and other, "trophic," ones, we compared the effects on the ...
Catsicas, M. +2 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 10, Page 3934-3963, 15 May 2026.Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli +13 more
wiley +1 more source
An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids [PDF]
, 2015 We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin.
Amey, Joanna S. +9 more
core +1 more source
Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
Marine Drugs, 2019 Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi +3 more
doaj +1 more source
Decreased cardiac excitability secondary to reduction of sodium current may be a significant contributor to reduced contractility in a rat model of sepsis [PDF]
, 2014 Pembelajaran pada hakekatnya adalah proses interaksi antara peserta didik dengan lingkungannya. Pembelajaran merupakan aktualisasi kurikulum yang menuntut keaktifan guru dalam menciptakan dan menumbuhkan kegiatan peserta didik sesuai dengan rencana yang ...
Andrew Koesters +2 more
core +2 more sources
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
Toxins, 2014 Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane +4 more
doaj +1 more source
The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]
, 2015 BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O +3 more
core +1 more source
Toxins, 2017 Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal +7 more
doaj +1 more source
Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]
Toxins (Basel), 2022 Hassoun AER +6 more
europepmc +1 more source