Results 91 to 100 of about 48,663 (220)

Toxic mechanism and detection methods of tetrodotoxin [PDF]

MATEC Web of Conferences
Tetrodotoxin (TTX) was first isolated in the early 20th century and has significant public health implications, especially in areas where puffer fish are consumed, such as Japan.
Xu Yunzhe
doaj   +1 more source

The Microbial Community of Tetrodotoxin-Bearing and Non-Tetrodotoxin-Bearing Ribbon Worms (Nemertea) from the Sea of Japan

Marine Drugs, 2020
A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora
Daria I. Melnikova, Timur Yu. Magarlamov   +1 more
doaj   +1 more source

Cancer: A bioelectric disease?

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The membrane potential (Vm) has emerged as a systems‐level regulator of cancer cell behaviour, linking ion channel activity to processes such as proliferation, differentiation and therapeutic response. This framework provides a roadmap for translating Vm measurement and validation into bioelectric precision medicine, integrating multi‐omics and ...
Celine Desoyer, Roko Šupe, Sahar Ghorbanpour, Debkalpa Goswami, Mina Khalaj, Nazanin Karami, Dagmar Brislinger, Charlotte A. E. Hauser, Christian Baumgartner   +8 more
wiley   +1 more source

Dynamische Blockierung TTX-resistenter Natriumkanäle durch Lokalanästhetika [PDF]

, 2003
In der vorliegenden Arbeit wurden grundlegende Eigenschaften von Natriumkanälen untersucht. Hierbei galt das besondere Augenmerk dem TTX-resistenten Natriumkanal in peripheren sensiblen Neuronen.
Pullmann, Martin
core   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Recent research progress in tetrodotoxin detection and quantitative analysis methods

Frontiers in Chemistry
Tetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health.
Chao Lin, Qirong Li, Dong Liu, Qiang Feng, Hengzong Zhou, Bohe Shi, Xinxin Zhang, Yurui Hu, Xinmiao Jiang, Xiaoming Sun, Dongxu Wang   +10 more
doaj   +1 more source

Seasonal Changes in the Tetrodotoxin Content of the Flatworm Planocera multitentaculata

Marine Drugs, 2017
Tetrodotoxin (TTX) is a potent neurotoxin that acts specifically on voltage-gated sodium channels on excitable membranes of muscle and nerve tissues. The biosynthetic process for TTX is unclear, although marine bacteria are generally thought to be the ...
Riko Yamada, Tadasuke Tsunashima, Mitsuki Takei, Tatsunori Sato, Yoshiki Wajima, Makoto Kawase, Shotaro Oshikiri, Yusuke Kajitani, Keita Kosoba, Hiroyuki Ueda, Koko Abe, Shiro Itoi, Haruo Sugita   +12 more
doaj   +1 more source

Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]

, 2006
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol, Djouhri, Laiche, Fang, Xin, Dr., Lawson, Sally N., McMullan, Simon, Okuse, Kenji, Waxman, Stephen G.   +6 more
core   +1 more source

A Scoping Review of Non‐Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle, Oliver M. Lowden, Rhea E. Sullivan, Taryn E. McFadden, Jennifer E. Nyland   +4 more
wiley   +1 more source

Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders

The Journal of Clinical Investigation
Multiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
doaj   +1 more source