Results 91 to 100 of about 27,116 (203)
Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe [PDF]
Tetrodotoxin (TTX) is a defence toxin most commonly found in marine organisms, and amphibians are the only land vertebrates (tetrapods) which are known to produce TTX.
Wagstaff, RM
core +2 more sources
Recent research progress in tetrodotoxin detection and quantitative analysis methods
Frontiers in ChemistryTetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health.
Chao Lin +10 more
doaj +1 more source
Spatial variability and depuration of tetrodotoxin in the bivalve Paphies australis from New Zealand
Toxicon: X, 2019 Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications globally. Despite its potency and widespread occurrence in taxonomically diverse species, the primary source of TTX remains uncertain.
Laura Biessy +5 more
doaj +1 more source
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Foulkes, T +8 more
core
, 2010 Lethal chemical defenses in prey species can have profound effects on interactions with predators. The presence of lethal defenses in prey can correct the selective imbalance suggested by the life-dinner principle in which the fitness consequences of an ...
Edmund D. Brodie +6 more
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Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing
The Journal of Physiology, EarlyView.Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
The Journal of Clinical InvestigationMultiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
doaj +1 more source
Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
Marine Drugs, 2019 Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza +4 more
wiley +1 more source