Results 111 to 120 of about 27,116 (203)
Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu +9 more
wiley +1 more source
Electrostatic tuning of NaV channel activation by the domain II S3–S4 extracellular loop
The Journal of Physiology, Volume 604, Issue 17, Page 7210-7224, 1 September 2026.Abstract figure legend Voltage‐gated sodium (NaV) channels are critical for electrical signalling, yet the molecular determinants that tune isoform‐specific activation remain incompletely understood. Here, we show that charged amino acids in the extracellular DII S3–S4 loop of NaV1.7 play a key role in setting voltage‐dependent activation.
Ashvriya Thapa +5 more
wiley +1 more source
Acute toxicity of tetrodotoxin (TTX). Should tetrodotoxin be part of the PSP class of toxins?
, 2019 Tetrodotoxin recognized as an emerging risk by international regulators Issues with TTX from pufferfish are well-known throughout history. TTX more recently identified in bivalve molluscs: -- Japan (scallops) -- NZ (pipi) -- UK (mussels and oysters ...
Sarah Finch (15395276)
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Oestrogen modulates stress‐induced vagally‐dependent gastric responses to oxytocin
The Journal of Physiology, Volume 604, Issue 18, Page 7570-7593, 15 September 2026.Abstract figure legend In female rats, PVNCRF‐DMV neurons and DMV CRF1 receptors are tonically active, allowing oxytocin (OXT) to modulate inhibitory GABAergic transmission to DMV neurons. Parasympathetic control of gastric functions involves engagement of non‐adrenergic non‐cholinergic vagal efferent pathways, but recruitment of distinct pathways ...
Ruchi Bhagat +2 more
wiley +1 more source
Toxins, 2018 Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang +6 more
doaj +1 more source
A Stereoselective Synthesis of (−)-Tetrodotoxin
, 2016 An asymmetric synthesis of the fugu fish poison, (−)-tetrodotoxin, is described. The route to this extraordinary target employs a number of unique transformations, foremost of which are two stereospecific C−H bond functionalization reactions. Accordingly,
Andrew Hinman (2993631) +1 more
core +1 more source
Experimental PhysiologyGut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Richard J. Amedzrovi Agbesi +4 more
doaj +1 more source
Marine DrugsTetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms.
Xinxin Zhang +6 more
doaj +1 more source
Tetrodotoxin (TTX) is an extremely potent paralytic toxin responsible for yearly illness and death around the world. A clinical measurement is necessary to confirm exposure because symptoms of TTX intoxication cannot be distinguished from other paralytic
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Purification and Characterization of Tetrodotoxin-binding Substance in Shore Crab Hemolymph [PDF]
, 2001 P(論文)テトロドトキシン(TTX)は古くからフグ毒の主成分として知られる。1964年にカリフォルニアイモリの毒がTTXに同定されて以来,これまでに微生物から両生類にいたる多種の生物に存在することが明らかにされてきた。TTXは神経細胞のNaチャンネルを選択的にブロックして,神経の興奮を阻害する作用を持つ神経毒であるとされている。TTXを保有しない一般の硬骨魚類のTTXの腹腔内投与に対する抵抗性はマウスと同程度の体重20g当たり約1MUである。これに対して ...
楠田, 理一 +9 more
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