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Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2016
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Mary Lehane, Ambrose Furey
exaly +4 more sources
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Mary Lehane, Ambrose Furey
exaly +4 more sources
THE SCENT OF DANGER: TETRODOTOXIN (TTX) AS AN OLFACTORY CUE OF PREDATION RISK
Ecological Monographs, 2006Larvae of the California newt (Taricha torosa) exhibit striking predator-avoidance behavior, escaping to refuges in response to a chemical cue from cannibalistic adults. In laboratory flow-tank experiments, stream water collected near free-ranging adults induced hiding responses in 100% of the larvae tested.
Richard K Zimmer +2 more
exaly +3 more sources
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
The genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) was evaluated in a battery of in vitro and in vivo genotoxicity assays. These comprised a bacterial reverse-mutation assay (Ames test), an in vitro human lymphocyte chromosome-aberration assay, an in vivo mouse bone-marrow micronucleus assay and an in vivo rat-liver UDS assay. Maximum
Antonio Guzman
exaly +4 more sources
The genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) was evaluated in a battery of in vitro and in vivo genotoxicity assays. These comprised a bacterial reverse-mutation assay (Ames test), an in vitro human lymphocyte chromosome-aberration assay, an in vivo mouse bone-marrow micronucleus assay and an in vivo rat-liver UDS assay. Maximum
Antonio Guzman
exaly +4 more sources
Toxicon, 2021
Adults of the ectoparasitic copepod Caligus fugu found on tetrodotoxin (TTX)-bearing pufferfish such as Takifugu alboplumbeus and Takifugu flavipterus are known to accumulate TTX in body tissues and parts other than the ovaries, oviducts, eggs, and cuticles.
Koichi Ikeda +2 more
exaly +3 more sources
Adults of the ectoparasitic copepod Caligus fugu found on tetrodotoxin (TTX)-bearing pufferfish such as Takifugu alboplumbeus and Takifugu flavipterus are known to accumulate TTX in body tissues and parts other than the ovaries, oviducts, eggs, and cuticles.
Koichi Ikeda +2 more
exaly +3 more sources
Toxicon, 2006
In May 2002, two parasitic copepods, Pseudocaligus fugu and Taeniacanthus sp., were collected from the body surface and gill of the grass puffer Takifugu niphobles, respectively, in Takehara city, Hiroshima Prefecture, faced with Seto Inland Sea located in the western part of Japan.
K. Ito +6 more
semanticscholar +3 more sources
In May 2002, two parasitic copepods, Pseudocaligus fugu and Taeniacanthus sp., were collected from the body surface and gill of the grass puffer Takifugu niphobles, respectively, in Takehara city, Hiroshima Prefecture, faced with Seto Inland Sea located in the western part of Japan.
K. Ito +6 more
semanticscholar +3 more sources
Toxicon, 2019
Tetrodotoxin (TTX) is a neurotoxin mainly responsible for severe neurological illness, and okadaic acid (OA) is another important lipophilic toxin to humans.
Sumei Ling +9 more
semanticscholar +1 more source
Tetrodotoxin (TTX) is a neurotoxin mainly responsible for severe neurological illness, and okadaic acid (OA) is another important lipophilic toxin to humans.
Sumei Ling +9 more
semanticscholar +1 more source
Toxicon, 2003
Micro-distributions of tetrodotoxin (TTX) in the skin of a brackish-water puffer Tetraodon nigroviridis were investigated by means of a monoclonal anti-TTX antibody under light and transmission electron microscope. In light microscopy TTX antigen was visualized as brown color in undifferentiated basal cells and succiform cells of the skin, while in ...
Y. Mahmud +8 more
semanticscholar +3 more sources
Micro-distributions of tetrodotoxin (TTX) in the skin of a brackish-water puffer Tetraodon nigroviridis were investigated by means of a monoclonal anti-TTX antibody under light and transmission electron microscope. In light microscopy TTX antigen was visualized as brown color in undifferentiated basal cells and succiform cells of the skin, while in ...
Y. Mahmud +8 more
semanticscholar +3 more sources
The Journal of Pharmacology and Experimental Therapeutics, 2007
The excitability of sensory neurons depends on the expression of various voltage-gated Na+ channel isoforms. The tetrodotoxin-resistant (TTXr) Na+ channel Na(v)1.8 accounts for the electroresponsiveness of nociceptive neurons and contributes to inflammatory and neuropathic pain.
A. Leffler +3 more
semanticscholar +3 more sources
The excitability of sensory neurons depends on the expression of various voltage-gated Na+ channel isoforms. The tetrodotoxin-resistant (TTXr) Na+ channel Na(v)1.8 accounts for the electroresponsiveness of nociceptive neurons and contributes to inflammatory and neuropathic pain.
A. Leffler +3 more
semanticscholar +3 more sources
Biosensors & bioelectronics, 2021
The development of ultrasensitive, reliable, and facile detection technologies for trace tetrodotoxin (TTX) is challenging. We presented a facile dual-mode aptamer-based biosensor (aptasensor) for ultrasensitive fluorescence and surface-enhanced Raman ...
Shan-Du Liu +7 more
semanticscholar +1 more source
The development of ultrasensitive, reliable, and facile detection technologies for trace tetrodotoxin (TTX) is challenging. We presented a facile dual-mode aptamer-based biosensor (aptasensor) for ultrasensitive fluorescence and surface-enhanced Raman ...
Shan-Du Liu +7 more
semanticscholar +1 more source
Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2022
Saxitoxin (STX) and tetrodotoxin (TTX) are widely distributed and extremely harmful marine toxins, it is certainly worth to spend effort to develop facile methods to detect them in sea food for human safety.
Xilin Dou +4 more
semanticscholar +1 more source
Saxitoxin (STX) and tetrodotoxin (TTX) are widely distributed and extremely harmful marine toxins, it is certainly worth to spend effort to develop facile methods to detect them in sea food for human safety.
Xilin Dou +4 more
semanticscholar +1 more source