Results 161 to 170 of about 19,032 (194)

First identification of tetrodotoxin (TTX) in the flatworm Stylochoplana sp.; a source of TTX for the sea slug Pleurobranchaea maculata

Toxicon, 2015
High concentrations of the neurotoxin tetrodotoxin (TTX) were detected by liquid chromatography-mass spectrometry (LC-MS) in the Platyhelminthes Stylochoplana sp. from Pilot Bay (Tauranga, New Zealand). This is the first detection of TTX in this genus. Concentrations were monitored from March to November (2013) and found to significantly decrease from ...
Lauren Salvitti, Susanna A Wood, David I Taylor   +2 more
exaly   +3 more sources

Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor

Sensors and Actuators B: Chemical, 2008
Abstract We report the quantitative antibody-based detection of a low-molecular weight molecule tetrodotoxin (TTX) (∼319 Da) by inhibition assay with a surface plasmon resonance (SPR) sensor. A novel anti-TTX antibody sensing surface was developed by chemically immobilizing TTX on a gold film with a mixed self assembled monolayer (SAM) consisting of ...
Jon Ladd, Sherwood Hall, Shaoyi Jiang
exaly   +2 more sources

Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons

Brain Research Bulletin, 2000
Ketamine, a general anesthetic, has been reported to block sodium channels. Two types of Na(+) channels, tetrodotoxin (TTX)-sensitive (TTX-s) and TTX-resistant (TTX-r), are expressed in dorsal root ganglion (DRG) neurons. The present study was to investigate the effects of ketamine on both types, particularly on TTX-r channels, using whole-cell patch ...
Z Q Zhao
exaly   +3 more sources

LC-MS/MS method for the determination of tetrodotoxin (TTX) on a triple quadruple mass spectrometer

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2016
Tetrodotoxin (TTX), often referred to as the 'puffer fish' poison, is a marine toxin and it has been identified as the agent responsible for many food poisoning incidents around the world. It is a neurotoxin that blocks voltage-gated sodium channels, resulting in respiratory paralysis and even death in severe cases.
Mary Lehane, Ambrose Furey
exaly   +3 more sources

THE SCENT OF DANGER: TETRODOTOXIN (TTX) AS AN OLFACTORY CUE OF PREDATION RISK

Ecological Monographs, 2006
Larvae of the California newt (Taricha torosa) exhibit striking predator-avoidance behavior, escaping to refuges in response to a chemical cue from cannibalistic adults. In laboratory flow-tank experiments, stream water collected near free-ranging adults induced hiding responses in 100% of the larvae tested.
Richard K Zimmer, Ryan P Ferrer, Lee B Kats   +2 more
exaly   +2 more sources

Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
The genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) was evaluated in a battery of in vitro and in vivo genotoxicity assays. These comprised a bacterial reverse-mutation assay (Ames test), an in vitro human lymphocyte chromosome-aberration assay, an in vivo mouse bone-marrow micronucleus assay and an in vivo rat-liver UDS assay. Maximum
Antonio Guzman
exaly   +3 more sources

A rapid method for tetrodotoxin (TTX) determination by LC-MS/MS from small volumes of human serum, and confirmation of pufferfish poisoning by TTX monitoring

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2015
A simple and rapid detection method for tetrodotoxin (TTX), a powerful sodium channel blocker, in small volumes of the serum of patients with pufferfish poisoning, was developed using an ultrafiltration spin column. The separation and identification of TTX was performed by liquid chromatography (LC) with a multi-mode ODS column and tandem mass ...
Kazunari, Tsujimura, Kimiko, Yamanouchi
exaly   +3 more sources

A Global Retrospective Study on Human Cases of Tetrodotoxin (TTX) Poisoning after Seafood Consumption [PDF]

Food Reviews International, 2020
The presented global retrospective study on human cases of tetrodotoxin (TTX) intoxication caused by seafood consumption was aimed at updating the relative risk according to seafood product categories (fish, gastropods, cephalopods, arthropods) and ...
Valentina Meucci, Daniele Nucera, Andrea Armani   +2 more
exaly   +2 more sources

Seafood cross-contamination by tetrodotoxin (TTX): management of an unusual route of exposure

Journal of Consumer Protection and Food Safety, 2023
In this study, liquid chromatography with tandem mass spectroscopy was applied to detect Tetrodotoxin and analogues (TTXs) on pufferfish (Sphoeroides marmoratus) tissues, accidentally found in the stomach of a cuttlefish (Sepia officinalis). The cuttlefish tissues were also analysed.
Tinacci L., Malloggi C., Giusti A., Galli F., Dall'Ara S., Armani A.   +5 more
openaire   +2 more sources

Acute cardiovascular, antiarrhythmic and toxic effects of tetrodotoxin (TTX) in unanesthetized dogs

Toxicology and Applied Pharmacology, 1972
Abstract Five unanesthetized dogs were given iv doses of 0.3, 0.6, 1.2, 2.4 and 4.8 μg/kg of TTX infused over 5 min periods at 65 min intervals. In similar experiments 4 anesthetized dogs were given serial doses of saline. Emesis occurred in 3 or 4 dogs after each dose of TTX, and the highest dose produced respiratory arrest and death in 4 of the 5 ...
B R, Duce, H S, Feldman, E R, Smith
openaire   +2 more sources