Results 81 to 90 of about 19,032 (194)

Seasonal Changes in the Tetrodotoxin Content of the Flatworm Planocera multitentaculata

Marine Drugs, 2017
Tetrodotoxin (TTX) is a potent neurotoxin that acts specifically on voltage-gated sodium channels on excitable membranes of muscle and nerve tissues. The biosynthetic process for TTX is unclear, although marine bacteria are generally thought to be the ...
Riko Yamada, Tadasuke Tsunashima, Mitsuki Takei, Tatsunori Sato, Yoshiki Wajima, Makoto Kawase, Shotaro Oshikiri, Yusuke Kajitani, Keita Kosoba, Hiroyuki Ueda, Koko Abe, Shiro Itoi, Haruo Sugita   +12 more
doaj   +1 more source

GLP‐1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels

Microcirculation, Volume 33, Issue 5, July 2026.
ABSTRACT Objectives Recent clinical studies have suggested that glucagon‐like peptide‐1 receptor (GLP‐1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. In this study, we aimed to (1) determine if GLP‐1Rs are present in the lymphatic vasculature and characterize their expression, and (2) assess the ...
Mary E. Schulz, Victoria L. Akerstrom, Joseph H. Dayan, Jorge A. Castorena‐Gonzalez   +3 more
wiley   +1 more source

Novel Polyclonal Antibody Raised against Tetrodotoxin Using Its Haptenic Antigen Prepared from 4,9-anhydrotetrodotoxin Reacted with 1,2-Ethaneditiol and Further Reacted with Keyhole Limpet Hemocyanin

Toxins, 2019
A novel polyclonal antibody against tetrodotoxin (TTX) was raised using its haptenic antigen, where 4,9-anhydroTTX was reacted with 1,2-ethanedithiol and this derivative was further reacted with keyhole limpet hemocyanin (KLH).
Shigeru Sato, Suzuka Takaishi, Ko Yasumoto, Shugo Watabe   +3 more
doaj   +1 more source

Investigating Diet as the Source of Tetrodotoxin in the Grey Side-gilled Sea Slug, Pleurobranchaea maculata

, 2014
Pleurobranchaea maculata (grey-side gilled sea slug) was discovered to contain the neurotoxin tetrodotoxin (TTX) in 2009 after a spate of dog poisoning cases on the beaches of Auckland, New Zealand.
Khor, Serena
core  

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Toxins, 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane, Mary Lehane, Madhurima Dikshit, Alan O'Riordan, Ambrose Furey   +4 more
doaj   +1 more source

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +7 more
doaj   +1 more source

Concentrations of Tetrodotoxin (TTX) and Its Analogue 4,9-Anhydro TTX in Different Tissues of the Silver-Cheeked Pufferfish (Lagocephalus sceleratus, Gmelin, 1789) Caught in the South-Eastern Mediterranean Sea, Lebanon. [PDF]

Toxins (Basel), 2022
Hassoun AER, Ujević I, Jemaa S, Roje-Busatto R, Mahfouz C, Fakhri M, Nazlić N.   +6 more
europepmc   +1 more source

Tetrodotoxin-resistant sodium channels in neuropathic pain

, 2000
Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury.
Jenny Fjell Hjelmström (19527955)
core  

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels [PDF]

, 2002
Mu-conotoxins are peptide inhibitors of voltage-sensitive sodium channels (VSSCs). Synthetic forms of mu-conotoxins PIIIA and PIIIA-(2-22) were found to inhibit tetrodotoxin (TTX)-sensitive VSSC current but had little effect on TTX-resistant VSSC current
Hill, Justine M., Alewood, Paul F., Gage, Peter W., Gage, Peter, Hill, James O, Craik, David J, Peter W. Gage, Nielsen, Katherine, Adams, David, Anna K. Hammarström, David J. Craik, Denise Adams, Hammarstrom, Anna, Adams, Denise, Justine M. Hill, Richard J. Lewis, Adams, David J., David J. Adams, Linda Thomas, Michael Watson, Craik, David J., Thomas, Linda, Lewis, Richard J., Watson, Michael, Lewis, Richard L, Paul F. Alewood, Nielsen, Katherine J., Hammarstrom, Anna K., Alewood, Paul F, Katherine J. Nielsen   +29 more
core   +1 more source